5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

Base Information

Chemical Name:5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate
CAS No.:1431328-98-1
Molecular Formula:C₃₁H₃₄FNO₄
Molecular Weight:503.614
Hs Code.:

Synonyms:5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

Suppliers and Price of 5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

There total 14 articles about 5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

: 1431328-98-1
5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

: 5-methyl 1a-(2-methyl-2-propanyl)(1aS,12bR)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

Guidance literature:: With carbon dioxide; In methanol; at 35 ℃; under 112511 Torr; Resolution of racemate;

Reference yield:

: 5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

: 1431328-98-1
5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

Guidance literature:: With carbon dioxide; In methanol; at 35 ℃; Concentration; Resolution of racemate;

Reference yield:

: 94569-84-3
2-bromo-5-fluorobenzaldehyde

: 1431328-98-1
5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3-quinuclidinol / N,N-dimethyl-formamide; water / 19 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 2 h / 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.08 h / 20 °C

3.2: 3 h / -47 - -20 °C

4.1: potassium acetate; palladium diacetate; tricyclohexylphosphine tetrafluoroborate / N,N-dimethyl acetamide / 6 h / 122 °C / Inert atmosphere

5.1: potassium tert-butylate; trimethylsulfoxonium iodide / N,N-dimethyl-formamide / 3 h / 20 °C

6.1: carbon dioxide / methanol / 35 °C / Resolution of racemate

With dmap; carbon dioxide; potassium tert-butylate; potassium acetate; trimethylsulfoxonium iodide; palladium diacetate; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine tetrafluoroborate; 3-quinuclidinol; In methanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;