tert-butyl 2-(acetoxy(2-bromo-5-fluorophenyl)methyl)acrylate

Base Information

• Chemical Name: tert-butyl 2-(acetoxy(2-bromo-5-fluorophenyl)methyl)acrylate
• CAS No.: 1431328-94-7
• Molecular Formula: C₁₆H₁₈BrFO₄
• Molecular Weight: 373.219
• Mol file: 1431328-94-7.mol

Synonyms:tert-butyl 2-(acetoxy(2-bromo-5-fluorophenyl)methyl)acrylate

Chemical Property of tert-butyl 2-(acetoxy(2-bromo-5-fluorophenyl)methyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(acetoxy(2-bromo-5-fluorophenyl)methyl)acrylate

There total 3 articles about tert-butyl 2-(acetoxy(2-bromo-5-fluorophenyl)methyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyl 2-((2-bromo-5-fluorophenyl)(hydroxy)methyl)acrylate (1431328-93-6) + acetic anhydride (108-24-7) → tert-butyl 2-(acetoxy(2-bromo-5-fluorophenyl)methyl)acrylate (1431328-94-7)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

2-bromo-5-fluorobenzaldehyde (94569-84-3) → tert-butyl 2-(acetoxy(2-bromo-5-fluorophenyl)methyl)acrylate (1431328-94-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-quinuclidinol / N,N-dimethyl-formamide; water / 19 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 2 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; 3-quinuclidinol; In dichloromethane; water; N,N-dimethyl-formamide; 1: |Baylis-Hillman Reaction;

Reference yield:

tert-Butyl acrylate (1663-39-4,25232-27-3) → tert-butyl 2-(acetoxy(2-bromo-5-fluorophenyl)methyl)acrylate (1431328-94-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-quinuclidinol / N,N-dimethyl-formamide; water / 19 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 2 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; 3-quinuclidinol; In dichloromethane; water; N,N-dimethyl-formamide; 1: |Baylis-Hillman Reaction;

upstream raw materials:

tert-butyl 2-((2-bromo-5-fluorophenyl)(hydroxy)methyl)acrylate

acetic anhydride

2-bromo-5-fluorobenzaldehyde

tert-Butyl acrylate

Downstream raw materials:

10-methyl 6-(2-methyl-2-propanyl) 13-cyclohexyl-3-fluoro-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylate

5-methyl 1a-(2-methyl-2-propanyl)(1aR,12bS)-8-cyclohexyl-11-fluoro-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

(1aS,12bR)-8-cyclohexyl-11-fluoro-5-(methoxycarbonyl)-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid

(E)-methyl 1-(3-(2-bromo-5-fluorophenyl)-2-(tert-butoxycarbonyl)allyl)-3-cyclohexyl-1H-indole-6-carboxylate