1-bromo-3-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-1,2,3,4-tetrahydro-naphthalene

Base Information

Chemical Name:1-bromo-3-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-1,2,3,4-tetrahydro-naphthalene
CAS No.:807609-63-8
Molecular Formula:C₂₄H₂₀BrF₃O
Molecular Weight:461.321
Hs Code.:

Synonyms:1-bromo-3-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-1,2,3,4-tetrahydro-naphthalene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-bromo-3-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-1,2,3,4-tetrahydro-naphthalene

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Technology Process of 1-bromo-3-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-1,2,3,4-tetrahydro-naphthalene

There total 8 articles about 1-bromo-3-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-1,2,3,4-tetrahydro-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 103772-30-1
1,2,3,4-tetrahydro-3-[4-(4-trifluoromethylbenzyloxy)phenyl]naphthalen-1-ol

: 807609-63-8
1-bromo-3-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-1,2,3,4-tetrahydro-naphthalene

Guidance literature:: With phosphorus tribromide; In dichloromethane; at -10 ℃; for 1h;
DOI:10.1016/j.bmcl.2004.09.009

Reference yield:

: 1023-17-2
4-methoxyphenyl benzyl ketone

: 807609-63-8
1-bromo-3-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-1,2,3,4-tetrahydro-naphthalene

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / Zn; I₂ / benzene / 1 h / Heating

2: 90 percent / Et₃SiH; TFA; BF₃*Et₂O / CH₂Cl₂ / 8 h / Heating

3: 92 percent / aq. KOH / 8 h / Heating

4: 85 percent / polyphosphoric acid / 1 h / 80 °C

5: 93 percent / HBr; AcOH / 6 h / Heating

6: 67 percent / NaH / tetrahydrofuran / 1 h / 0 °C

7: 87 percent / NaBH₄ / methanol / 2 h / 20 °C

8: 50 percent / PBr₃ / CH₂Cl₂ / 1 h / -10 °C

With triethylsilane; potassium hydroxide; sodium tetrahydroborate; PPA; boron trifluoride diethyl etherate; hydrogen bromide; iodine; phosphorus tribromide; sodium hydride; acetic acid; trifluoroacetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane; benzene; 1: Reformatsky reaction;
DOI:10.1016/j.bmcl.2004.09.009

Reference yield:

: 61696-79-5
3,4-dihydro-3-(4-methoxyphenyl)naphthalene-1(2H)-one

: 807609-63-8
1-bromo-3-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-1,2,3,4-tetrahydro-naphthalene

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / HBr; AcOH / 6 h / Heating

2: 67 percent / NaH / tetrahydrofuran / 1 h / 0 °C

3: 87 percent / NaBH₄ / methanol / 2 h / 20 °C

4: 50 percent / PBr₃ / CH₂Cl₂ / 1 h / -10 °C

With sodium tetrahydroborate; hydrogen bromide; phosphorus tribromide; sodium hydride; acetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.09.009