tert-butyl (4-{[({1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl}-amino)carbonyl]amino}-3,5-diisopropylphenyl)carbamate

Base Information

• Chemical Name: tert-butyl (4-{[({1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl}-amino)carbonyl]amino}-3,5-diisopropylphenyl)carbamate
• CAS No.: 437763-93-4
• Molecular Formula: C₃₉H₅₁N₅O₆
• Molecular Weight: 685.864
• Mol file: 437763-93-4.mol

Synonyms:tert-butyl (4-{[({1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl}-amino)carbonyl]amino}-3,5-diisopropylphenyl)carbamate

Chemical Property of tert-butyl (4-{[({1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl}-amino)carbonyl]amino}-3,5-diisopropylphenyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (4-{[({1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl}-amino)carbonyl]amino}-3,5-diisopropylphenyl)carbamate

There total 17 articles about tert-butyl (4-{[({1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl}-amino)carbonyl]amino}-3,5-diisopropylphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl [4-({[(4-{3-[3-(benzyloxy)propoxy]phenyl}-1-butyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)amino]carbonyl}amino)-3,5-diisopropylphenyl]carbamate (476371-02-5) → tert-butyl (4-{[({1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl}-amino)carbonyl]amino}-3,5-diisopropylphenyl)carbamate (437763-93-4)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In methanol; at 20 ℃; for 5h;

DOI:10.1016/j.tet.2005.08.009

Reference yield:

1-[3-(benzyloxy)propoxy]-3-bromobenzene (458558-10-6) → tert-butyl (4-{[({1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl}-amino)carbonyl]amino}-3,5-diisopropylphenyl)carbamate (437763-93-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: Mg; I₂ / tetrahydrofuran / 1.5 h / Heating

1.2: 51 percent / B(OMe)3 / tetrahydrofuran / -10 - 20 °C

2.1: 86 percent / cesium carbonate / Pd(PPh₃)4 / dioxane / 4 h / Heating

3.1: 100 percent / zinc; AcOH / methanol / 1.5 h / Heating

4.1: tetrahydrofuran / 20 °C

5.1: 456 mg / DMAP / dimethylformamide / 20 °C

6.1: 100 percent / hydrogen; acetic acid / Pd/C / methanol / 5 h / 20 °C

With dmap; hydrogen; iodine; caesium carbonate; magnesium; acetic acid; zinc; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; 2.1: Suzuki reaction;

DOI:10.1016/j.tet.2005.08.009

Reference yield:

4-amino-2,6-diisopropylaniline (455288-51-4) → tert-butyl (4-{[({1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl}-amino)carbonyl]amino}-3,5-diisopropylphenyl)carbamate (437763-93-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 292 mg / NaOH / methanol / 2 h / 20 °C

2: 456 mg / DMAP / dimethylformamide / 20 °C

3: 100 percent / hydrogen; acetic acid / Pd/C / methanol / 5 h / 20 °C

With dmap; sodium hydroxide; hydrogen; acetic acid; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2005.08.009

upstream raw materials:

tert-butyl [4-({[(4-{3-[3-(benzyloxy)propoxy]phenyl}-1-butyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)amino]carbonyl}amino)-3,5-diisopropylphenyl]carbamate

4-amino-2,6-diisopropylaniline

1-[3-(benzyloxy)propoxy]-3-bromobenzene

tert-butyl (4-amino-3,5-diisopropylphenyl)carbamate