458558-10-6

Upstream product

• 591-20-8 3-Bromophenol 
• 54314-84-0 1-[(3-bromopropoxy)methyl]-benzene 

Downstream Products

• 458558-11-7 [3-(3-benzyloxypropoxy)phenyl](2-chloropyridin-3-yl)methanone 
• 476371-02-5 tert-butyl [4-({[(4-{3-[3-(benzyloxy)propoxy]phenyl}-1-butyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)amino]carbonyl}amino)-3,5-diisopropylphenyl]carbamate 
• 437763-93-4 tert-butyl (4-{[({1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl}-amino)carbonyl]amino}-3,5-diisopropylphenyl)carbamate 
• 455288-42-3 {4-[3-(3-benzyloxy-propoxy)-phenyl]-1-butyl-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl}-carbamic acid phenyl ester 
• 476371-00-3 4-{3-[3-(benzyloxy)propoxy]phenyl}-1-butyl-3-nitro-1,8-naphthyridin-2(1H)-one 
• 458558-16-2 N-{3-[3-(3-benzyloxypropoxy)benzoyl]pyridin-2-yl}-N-butyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide 
• 458558-13-9 [3-(3-benzyloxypropoxy)phenyl](2-butylaminopyridin-3-yl)methanone 
• 259225-38-2 3-amino-4-{3-[3-(benzyloxy)propoxy]phenyl}-1-butyl-1,8-naphthyridin-2(1H)-one 
• 476370-99-7 {3-[3-(benzyloxy)propoxy]phenyl}boronic acid 

Relevant academic research and scientific papers

Synthesis of SMP-797: A new potent ACAT inhibitor

A potent ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor SMP-797 was effectively synthesized by the urea formation of 3-amino-4-aryl-1,8- naphthyridin-2(1H)-one and 4-amino-2,6-diisopropylamine. The synthesis of the former compound involved the Suzuki coupling reaction as a key step, and the latter was prepared by the 4-selective nitration of 2,6-diisopropylaniline using 2,3,5,6-tetrabromo-4-methyl-4-nitro-2,5-cyclohexadienone.

A practical synthesis of 1-alkyl-3-amino-4-aryl-1,8-naphthyridin-2-(1H)-one, a partial structure of acat inhibitor SMP-797

3-Amino-4-[3-(3-benzyloxypropoxy)phenyl]-1-butyl-1,8-naphthyridin-2(1H)-one,which is a naphthyridine part of a potent ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor SMP-797, was effectively synthesized from m-bromophenol in 5 steps without isolati