4-(4-{5-[2-chloro-5-(3-trifluoromethyl-benzoylamino)-benzoylamino]-pyrimidin-5-ylamino}-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(4-{5-[2-chloro-5-(3-trifluoromethyl-benzoylamino)-benzoylamino]-pyrimidin-5-ylamino}-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1001340-05-1
• Molecular Formula: C₃₅H₃₄ClF₃N₆O₆S
• Molecular Weight: 759.206
• Mol file: 1001340-05-1.mol

Synonyms:4-(4-{5-[2-chloro-5-(3-trifluoromethyl-benzoylamino)-benzoylamino]-pyrimidin-5-ylamino}-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(4-{5-[2-chloro-5-(3-trifluoromethyl-benzoylamino)-benzoylamino]-pyrimidin-5-ylamino}-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-{5-[2-chloro-5-(3-trifluoromethyl-benzoylamino)-benzoylamino]-pyrimidin-5-ylamino}-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 5 articles about 4-(4-{5-[2-chloro-5-(3-trifluoromethyl-benzoylamino)-benzoylamino]-pyrimidin-5-ylamino}-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

4-(4-(5-amino-pyrimidin-2-ylamino)-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester (1001340-03-9) + 2-chloro-5-{[3-(trifluoromethyl)benzoyl]amino}benzoic acid (896160-35-3) → 4-(4-{5-[2-chloro-5-(3-trifluoromethyl-benzoylamino)-benzoylamino]-pyrimidin-5-ylamino}-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester (1001340-05-1)

Guidance literature:

2-chloro-5-{[3-(trifluoromethyl)benzoyl]amino}benzoic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In dichloromethane; at 20 ℃; for 1h;

4-(4-(5-amino-pyrimidin-2-ylamino)-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

4-(4-(5-nitro-pyrimidin-2-ylamino)-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester (1001340-01-7) → 4-(4-{5-[2-chloro-5-(3-trifluoromethyl-benzoylamino)-benzoylamino]-pyrimidin-5-ylamino}-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester (1001340-05-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen / Raney Nickel / 3 h

2.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / dichloromethane / 1 h / 20 °C

2.2: 18 h / 20 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrogen; Raney Nickel; In dichloromethane;

Reference yield:

4-(4-bromobenzenesulfonyl)piperidine-1-carboxylic acid tert-butyl ester (226398-62-5) → 4-(4-{5-[2-chloro-5-(3-trifluoromethyl-benzoylamino)-benzoylamino]-pyrimidin-5-ylamino}-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester (1001340-05-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 5 h / Heating / reflux

2.1: hydrogen / Raney Nickel / 3 h

3.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / dichloromethane / 1 h / 20 °C

3.2: 18 h / 20 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrogen; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;

upstream raw materials:

4-(4-(5-amino-pyrimidin-2-ylamino)-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester

2-chloro-5-{[3-(trifluoromethyl)benzoyl]amino}benzoic acid

4-(4-(5-nitro-pyrimidin-2-ylamino)-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester

2-chloro-5-aminobenzoic acid