(1R,3R,5R,6S,10R)-3-(benzyloxymethyl)-8-(tert-butyldimethylsiloxy)-6-(dimethyl(phenyl)silyl)-10-hydroxy-2-oxabicyclo[3.3.2]dec-7-en-9-one

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Chemical Name:(1R,3R,5R,6S,10R)-3-(benzyloxymethyl)-8-(tert-butyldimethylsiloxy)-6-(dimethyl(phenyl)silyl)-10-hydroxy-2-oxabicyclo[3.3.2]dec-7-en-9-one
CAS No.:1021603-65-5
Molecular Formula:C₃₁H₄₄O₅Si₂
Molecular Weight:552.858
Hs Code.:
Mol file:1021603-65-5.mol

Synonyms:(1R,3R,5R,6S,10R)-3-(benzyloxymethyl)-8-(tert-butyldimethylsiloxy)-6-(dimethyl(phenyl)silyl)-10-hydroxy-2-oxabicyclo[3.3.2]dec-7-en-9-one

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Chemical Property of (1R,3R,5R,6S,10R)-3-(benzyloxymethyl)-8-(tert-butyldimethylsiloxy)-6-(dimethyl(phenyl)silyl)-10-hydroxy-2-oxabicyclo[3.3.2]dec-7-en-9-one Edit

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Technology Process of (1R,3R,5R,6S,10R)-3-(benzyloxymethyl)-8-(tert-butyldimethylsiloxy)-6-(dimethyl(phenyl)silyl)-10-hydroxy-2-oxabicyclo[3.3.2]dec-7-en-9-one

There total 1 articles about (1R,3R,5R,6S,10R)-3-(benzyloxymethyl)-8-(tert-butyldimethylsiloxy)-6-(dimethyl(phenyl)silyl)-10-hydroxy-2-oxabicyclo[3.3.2]dec-7-en-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1021603-63-3
(R)-7-(benzyloxymethyl)-6,7-dihydrooxepin-3(2H)-one

: 412907-55-2
C₁₇H₂₈OSi₂

: 1021603-65-5
(1R,3R,5R,6S,10R)-3-(benzyloxymethyl)-8-(tert-butyldimethylsiloxy)-6-(dimethyl(phenyl)silyl)-10-hydroxy-2-oxabicyclo[3.3.2]dec-7-en-9-one

Guidance literature:: (R)-7-(benzyloxymethyl)-6,7-dihydrooxepin-3(2H)-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -80 ℃; for 0.333333h;

C₁₇H₂₈OSi₂; In tetrahydrofuran; at -80 - -15 ℃; for 0.416667h;

With 18-crown-6 ether; sodium hexamethyldisilazane; N-(benzenesulfonyl)-3-phenyloxaziridine; In tetrahydrofuran; at -70 ℃; for 0.666667h; diastereoselective reaction;
DOI:10.1021/ol8003595