1-chloro-2-methyl-cyclohexane

Base Information

• Chemical Name: 1-chloro-2-methyl-cyclohexane
• CAS No.: 931-09-9
• Molecular Formula: C₇H₁₃Cl
• Molecular Weight: 132.633
• Mol file: 931-09-9.mol

Synonyms:1-chloro-2-methyl-cyclohexane

Chemical Property of 1-chloro-2-methyl-cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-chloro-2-methyl-cyclohexane

There total 24 articles about 1-chloro-2-methyl-cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-trans-2-methylcyclohexanol (7443-52-9) → 1-methylcyclohex-1-ene (591-49-1) + 1-chloro-1-methylcyclohexane (931-78-2) + trans 1-chloro-2-methylcyclohexane (931-09-9,28046-82-4,28046-83-5) + cis 1-chloro-2-methylcyclohexane (931-09-9,28046-82-4,28046-83-5)

Guidance literature:

With bismuth(III) chloride; In tetrachloromethane; for 1h; Further byproducts given; Heating;

DOI:10.1016/S0040-4020(01)00013-8

Reference yield:

(+/-)-trans-2-methylcyclohexanol (7443-52-9) → 1-methylcyclohex-1-ene (591-49-1) + 1-chloro-1-methylcyclohexane (931-78-2) + trans 1-chloro-2-methylcyclohexane (931-09-9,28046-82-4,28046-83-5) + cis 1-chloro-2-methylcyclohexane (931-09-9,28046-82-4,28046-83-5)

Guidance literature:

With bismuth(III) chloride; In tetrachloromethane; for 1h; Further byproducts given; Heating;

DOI:10.1016/S0040-4020(01)00013-8

Reference yield:

C7H13ClO2S → rac-(1R,2R)-1-chloro-2-methylcyclohexane (931-09-9,28046-82-4,28046-83-5)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 0 ℃; for 1h; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jo3023439

upstream raw materials:

1-methylcyclohex-1-ene

hydrogenchloride

2-Methylcyclohexanol

phosphorus pentachloride

Downstream raw materials:

(+-)-cis-2-methyl-cyclohexanecarboxylic acid

trans-2-methylcyclohexanecarboxylic acid

methyl cyclohexane

4,1'dimethyl-cyclohexylbenzene

Refernces

• 1、 Quinn, Ryan K.,K?nst, Zef A.,Michalak, Sharon E.,Schmidt, Yvonne,Szklarski, Anne R.,Flores, Alex R.,Nam, Sangkil,Horne, David A.,Vanderwal, Christopher D.,Alexanian, Erik J.. "Site-Selective Aliphatic C-H Chlorination Using N-Chloroamides Enables a Synthesis of Chlorolissoclimide". supporting information. p. 696 - 702. Retrieved 2016/02/03.
• 2、 Delaude, Lionel,Laszlo, Pierre. "Regioselective Hydrochlorination of Olefins Is Favored by an Acidic Solid Catalyst". . p. 3705 - 3708. Retrieved 2007/10/02.