Technology Process of 2-bromo-1-(4-bromophenyl)ethanone
There total 9 articles about 2-bromo-1-(4-bromophenyl)ethanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
at 20 ℃;
for 4h;
Cooling with ice;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-Bromosuccinimide; toluene-4-sulfonic acid / 2 h / 100 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C / Cooling with ice; Inert atmosphere
With
N-Bromosuccinimide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: thionyl chloride / 3 h / 0 - 20 °C
2.1: dmap / acetonitrile / 18.5 h / 0 - 20 °C
3.1: lithium triethylborohydride / toluene / 1.17 h / -78 °C
3.2: 2 h / 20 °C
4.1: diethylzinc / toluene / 0.75 h / Cooling with ice
4.2: 18 h / 0 °C
5.1: hydrogenchloride / ethyl acetate / 20 °C
6.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice
7.1: lithium hydroxide monohydrate / methanol; water / 20 °C
8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 40 h / 20 °C / Inert atmosphere; Cooling with ice
With
hydrogenchloride; dmap; thionyl chloride; lithium hydroxide monohydrate; diethylzinc; lithium triethylborohydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile;
