5-{(E)-2-[2-(2-chloroethoxy)phenyl]vinyl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile

Base Information

• Chemical Name: 5-{(E)-2-[2-(2-chloroethoxy)phenyl]vinyl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile
• CAS No.: 1160918-79-5
• Molecular Formula: C₂₅H₂₁ClN₄O
• Molecular Weight: 428.921

Synonyms:5-{(E)-2-[2-(2-chloroethoxy)phenyl]vinyl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile

Chemical Property of 5-{(E)-2-[2-(2-chloroethoxy)phenyl]vinyl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile

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Technology Process of 5-{(E)-2-[2-(2-chloroethoxy)phenyl]vinyl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile

There total 1 articles about 5-{(E)-2-[2-(2-chloroethoxy)phenyl]vinyl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(4-methyl-1H-indol-5-yl)amino]-5-vinylnicotinonitrile (1160918-11-5) + 2-bromophenyl 2-chloroethyl ether (64010-12-4) → 5-{(E)-2-[2-(2-chloroethoxy)phenyl]vinyl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile (1160918-79-5)

Guidance literature:

With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 120 ℃; for 2h;

Reference yield:

1-methyl-piperazine (109-01-3) + 5-{(E)-2-[2-(2-chloroethoxy)phenyl]vinyl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile (1160918-79-5) → 4-[(4-methyl-1H-indol-5-yl)amino]-5-[(E)-2-{2-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}vinyl]nicotinonitrile (1160918-81-9)

Guidance literature:

With sodium iodide; In 1,2-dimethoxyethane; at 100 ℃; Sealed vial;

Reference yield:

pyrrolidine (123-75-1) + 5-{(E)-2-[2-(2-chloroethoxy)phenyl]vinyl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile (1160918-79-5) → 4-[(4-methyl-1H-indol-5-yl)amino]-5-{(E)-2-[2-(2-pyrrolidin-1-ylethoxy)phenyl]vinyl}nicotinonitrile (1160918-84-2)

Guidance literature:

With sodium iodide; In 1,2-dimethoxyethane; at 100 ℃; Sealed vial;

upstream raw materials:

4-[(4-methyl-1H-indol-5-yl)amino]-5-vinylnicotinonitrile

2-bromophenyl 2-chloroethyl ether

Downstream raw materials:

4-[(4-methyl-1H-indol-5-yl)amino]-5-{(E)-2-[2-(2-pyrrolidin-1-ylethoxy)phenyl]vinyl}nicotinonitrile

4-[(4-methyl-1H-indol-5-yl)amino]-5-[(E)-2-{2-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}vinyl]nicotinonitrile

(E)-tert-butyl 4-(2-(2-(2-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)pyridin-3-yl)vinyl)phenoxy)ethyl)piperazine-1-carboxylate

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