64010-12-4

Usage

Uses

Used in Pharmaceutical Industry:
1-BROMO-2-(2-CHLOROETHOXY)BENZENE is used as a chemical intermediate for the production of pharmaceuticals, contributing to the synthesis of various medicinal compounds due to its unique structure and reactivity.
Used in Dye Industry:
In the dye industry, 1-BROMO-2-(2-CHLOROETHOXY)BENZENE serves as an intermediate, playing a crucial role in the synthesis of different types of dyes that are used in various applications, such as textiles, plastics, and printing inks.
Used in Chemical Reactions:
1-BROMO-2-(2-CHLOROETHOXY)BENZENE is used as a solvent in chemical reactions, facilitating specific processes and improving the efficiency of certain chemical transformations.
Used in Agricultural Industry:
In the agricultural sector, 1-BROMO-2-(2-CHLOROETHOXY)BENZENE is used as a component in the manufacturing of herbicides and insecticides, helping to control pests and weeds that can damage crops.
Due to the potential health hazards and environmental risks associated with 1-BROMO-2-(2-CHLOROETHOXY)BENZENE, it is essential to follow proper handling and disposal procedures when using this chemical to minimize any adverse effects.

InChI:InChI=1/C8H8BrClO/c9-7-3-1-2-4-8(7)11-6-5-10/h1-4H,5-6H2

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 107-06-2 1,2-dichloro-ethane 

Downstream Products

• 496-16-2 2.3-dihydrobenzofuran 
• 95-56-7 2-hydroxybromobenzene 
• 108-95-2 phenol 
• 66826-78-6 5-bromo-2,3-dihydrobenzo[b]furan 
• 40492-52-2 2,3-dihydrobenzofuran-5-ol 
• 90843-31-5 1-(2,3-dihydrobenzofuran-5-yl)ethanone 
• 1160918-84-2 4-[(4-methyl-1H-indol-5-yl)amino]-5-{(E)-2-[2-(2-pyrrolidin-1-ylethoxy)phenyl]vinyl}nicotinonitrile 
• 1160918-81-9 4-[(4-methyl-1H-indol-5-yl)amino]-5-[(E)-2-{2-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}vinyl]nicotinonitrile 
• 1160918-79-5 5-{(E)-2-[2-(2-chloroethoxy)phenyl]vinyl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile 
• 64009-34-3 4-(2-Bromo-phenoxy)-2-(2,4-dichloro-phenyl)-butyric acid methyl ester 
• 64009-56-9 2-(2,4-Dichlorphenyl)-4-(2-bromphenoxy)-butanol 
• 64009-20-7 4-(2-Bromo-phenoxy)-2-(2,4-dichloro-phenyl)-butyronitrile 

Relevant academic research and scientific papers

FUSED PYRIMIDINONE MATRIX METALLOPROTEINASE INHIBITORS

Selective MMP-13 inhibitors are fused pyrimidinones of the formula or a pharmaceutically acceptable salt thereof, wherein: W, together with the carbon atoms to which it is attached, form a 5-membered ring diradical X is O, S, SO, SO2, NR5, or CH 2; B is O or NR5; or A and B are taken together to form--C≡C--; R1, R4, and R 5 are hydrogen, alkyl, alkenyl, alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, C1-C6 alkanoyl, or (CH2)n heteroaryl; R2 and R3 are hydrogen, alkyl, alkenyl, alkynyl CN, NO2, NR 4R5, (CH2)n cycloalkyl, (CH2) n aryl, or (CH2)n heteroaryl; R2 may further be halo; n is an integer of from 0 to 5; and R4 and R5 when taken together with a nitrogen to which they are both attached complete a 3-to 8-membered ring containing carbon atoms and optionally containing O, S, or N, and substituted or unsubstituted; with the proviso that R1 and R3 are not both selected from hydrogen and C1-C6 alkyl.

The Synthesis of 5-Substituted 2,3-Dihydrobenzofurans

The preparation of 2,3-dihydrobenzofurans 6 from 2-(2-bromophenoxy)ethyl chlorides 3 by reaction with magnesium in a development of the Parham cyclialkylation reaction is described.A high yielding procedure using phase-transfer catalysis has also been developed for the preparation of the intermediate chloroethyl ethers 3 from bromophenols 2.The 5-hydroxy derivative 15 may be obtained from 2,3-dihydrobenzofuran (6a) by reaction with electrophilic reagents followed by oxidation.