Technology Process of N-{5-acetyl-4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide
There total 6 articles about N-{5-acetyl-4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-acetamido-3-bromoacetophenone;
With
potassium acetate; bis(pinacol)diborane;
[1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride;
In
1,4-dioxane;
at 80 ℃;
for 2.5h;
Argon atmosphere;
1-(4-bromo-phenyl)-3-(2-chloro-benzyl)-1,3-dihydro-benzoimidazol-2-ylideneamine;
With
sodium carbonate;
[1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride;
In
1,2-dimethoxyethane;
at 150 ℃;
for 0.283333h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton
1.2: 0.25 h
2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C
3.1: water; acetonitrile / 18 h / 20 °C
4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation
5.1: potassium acetate; bis(pinacol)diborane / [1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride / 1,4-dioxane / 2.5 h / 80 °C / Argon atmosphere
5.2: 0.28 h / 150 °C / Microwave irradiation
With
tin(II) chloride dihdyrate; potassium acetate; triethylamine; bis(pinacol)diborane; potassium iodide;
[1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride;
In
1,4-dioxane; ethanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton
1.2: 0.25 h
2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C
3.1: water; acetonitrile / 18 h / 20 °C
4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation
5.1: potassium acetate; bis(pinacol)diborane / [1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride / 1,4-dioxane / 2.5 h / 80 °C / Argon atmosphere
5.2: 0.28 h / 150 °C / Microwave irradiation
With
tin(II) chloride dihdyrate; potassium acetate; triethylamine; bis(pinacol)diborane; potassium iodide;
[1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride;
In
1,4-dioxane; ethanol; water; acetonitrile;
