C₅₁H₆₀N₆O₂₂

Base Information

• Chemical Name: C₅₁H₆₀N₆O₂₂
• CAS No.: 673485-37-5
• Molecular Formula: C₅₁H₆₀N₆O₂₂
• Molecular Weight: 1109.06
• Mol file: 673485-37-5.mol

Synonyms:C₅₁H₆₀N₆O₂₂

Chemical Property of C₅₁H₆₀N₆O₂₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₁H₆₀N₆O₂₂

There total 13 articles about C₅₁H₆₀N₆O₂₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

4-Nitrophenyl chloroformate (7693-46-1) + [2-({4-[({2-[(2,6-bis-hydroxymethyl-4-methyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-methyl]-2,6-dimethoxy-phenoxycarbonyl}-methyl-amino)-ethyl]-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester (673485-36-4) → C51H60N6O22 (673485-37-5)

Guidance literature:

With dmap; In ethyl acetate;

DOI:10.1021/ja039052p

Reference yield:

2,6-bis(hydroxymethyl)-4-methylphenol (91-04-3) → C51H60N6O22 (673485-37-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 85 percent / imidazole / dimethylformamide / 2 h / 20 °C

2: 87.8 percent / Et₃N; DMAP / ethyl acetate / 0.33 h / 20 °C

3: 97.4 percent / dimethylformamide / 0.17 h / 20 °C

4: 77.5 percent / Amberlyst 15 / methanol / 2 h / 20 °C

5: TFA

6: 119.1 mg / triethylamine / dimethylformamide / 0.25 h

7: 36 percent / DMAP / ethyl acetate

With 1H-imidazole; dmap; Amberlyst 15; triethylamine; trifluoroacetic acid; In methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ja039052p

Reference yield:

syringic alcohol (530-56-3) → C51H60N6O22 (673485-37-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 52.8 percent / Et₃N / tetrahydrofuran / 1 h / 20 °C

2: 80.9 percent / dimethylformamide / 0.17 h / 20 °C

3: TFA

4: 169.4 mg / triethylamine / dimethylformamide / 0.25 h

5: 58.2 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 20 °C

6: 119.1 mg / triethylamine / dimethylformamide / 0.25 h

7: 36 percent / DMAP / ethyl acetate

With dmap; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ja039052p

upstream raw materials:

4-Nitrophenyl chloroformate

[2-({4-[({2-[(2,6-bis-hydroxymethyl-4-methyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-methyl]-2,6-dimethoxy-phenoxycarbonyl}-methyl-amino)-ethyl]-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester

2,6-bis(hydroxymethyl)-4-methylphenol

syringic alcohol