(S)-1,1-di([1,1'-biphenyl]-4-yl)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

Base Information

Chemical Name:(S)-1,1-di([1,1'-biphenyl]-4-yl)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one
CAS No.:845965-26-6
Molecular Formula:C₃₀H₂₅NO₂
Molecular Weight:431.534
Hs Code.:

Synonyms:(S)-1,1-di([1,1'-biphenyl]-4-yl)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

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Chemical Property of (S)-1,1-di([1,1'-biphenyl]-4-yl)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

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Technology Process of (S)-1,1-di([1,1'-biphenyl]-4-yl)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

There total 3 articles about (S)-1,1-di([1,1'-biphenyl]-4-yl)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 3315-91-1
4-biphenylylmagnesium bromide

: 77581-28-3,93423-88-2
(S)-proline-N-ethyl carbamate methyl ester

: 845965-26-6
(S)-1,1-di([1,1'-biphenyl]-4-yl)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

Guidance literature:: In tetrahydrofuran; at 0 - 65 ℃;
DOI:10.1021/jo048378t

Reference yield:

: 92-66-0
4-bromo-1,1'-biphenyl

: 77581-28-3,93423-88-2
(S)-proline-N-ethyl carbamate methyl ester

: 845965-26-6
(S)-1,1-di([1,1'-biphenyl]-4-yl)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

Guidance literature:: 4-bromo-1,1'-biphenyl; With magnesium; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

(S)-proline-N-ethyl carbamate methyl ester; In tetrahydrofuran; at 5 ℃; for 3h; Inert atmosphere; Reflux;

With water; ammonium chloride; In tetrahydrofuran; for 1h; Inert atmosphere;

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 845965-26-6
(S)-1,1-di([1,1'-biphenyl]-4-yl)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / K₂CO₃ / 0 - 20 °C

2: 70 percent / tetrahydrofuran / 0 - 65 °C

With potassium carbonate; In tetrahydrofuran;
DOI:10.1021/jo048378t