1-<amino>methyl>-3-nitrobenzene

Base Information

• Chemical Name: 1-<amino>methyl>-3-nitrobenzene
• CAS No.: 173952-01-7
• Molecular Formula: C₁₇H₁₄FN₃O₃
• Molecular Weight: 327.315
• Mol file: 173952-01-7.mol

Synonyms:1-<amino>methyl>-3-nitrobenzene

Chemical Property of 1-<amino>methyl>-3-nitrobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<amino>methyl>-3-nitrobenzene

There total 2 articles about 1-<amino>methyl>-3-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-nitrobenzylamine (7409-18-9) + 2-Fluoro-4-prop-2-ynylamino-benzoic acid (173951-98-9) → 1-<amino>methyl>-3-nitrobenzene (173952-01-7)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; for 16h;

DOI:10.1021/jm950645n

Reference yield:

tert-butyl 2-fluoro-4-(prop-2-ynylamino)benzoate (140373-03-1) → 1-<amino>methyl>-3-nitrobenzene (173952-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / CH₂Cl₂ / 3 h

2: 79 percent / diphenyl phosphorazidate, triethylamine / dimethylformamide / 16 h

With diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm950645n

Reference yield: 60.0%

2-(acetoxymethyl)-6-(bromomethyl)-3,4-dihydro-4-oxo-7-methylquinazolinone (161417-82-9) + 1-<amino>methyl>-3-nitrobenzene (173952-01-7) → Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester (173952-23-3)

Guidance literature:

With calcium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

DOI:10.1021/jm950645n

upstream raw materials:

3-nitrobenzylamine

2-Fluoro-4-prop-2-ynylamino-benzoic acid

tert-butyl 2-fluoro-4-(prop-2-ynylamino)benzoate

Downstream raw materials:

Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

4-[(2-Chloromethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-fluoro-N-(3-nitro-benzyl)-benzamide

2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-N-(3-nitro-benzyl)-benzamide