1,N(2)-ethenodeoxyguanosine

Base Information

• Chemical Name: 1,N(2)-ethenodeoxyguanosine
• CAS No.: 108929-11-9
• Molecular Formula: C12H13 N5 O4
• Molecular Weight: 291.266
• Mol file: 108929-11-9.mol

Synonyms:1,N2-Etheno-2'-deoxyguanosine;1,N2-Ethenodeoxyguanosine

Chemical Property of 1,N(2)-ethenodeoxyguanosine

Chemical Property:

• Vapor Pressure: 1.64E-30mmHg at 25°C
• Boiling Point: 847.2°Cat760mmHg
• Flash Point: 466.2°C
• PSA: 117.67000
• Density: 1.99g/cm³
• LogP: -0.98700

Purity/Quality:

97% ^*data from raw suppliers

1,N2-Etheno-2’-deoxyguanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1, N2-Etheno-2’-deoxyguanosine is the unlabeled form of 1, N2-Etheno-2’-deoxyguanosine-13C5 (E677903), which is caused by exposure to pollutants. It is an isotopically labeled analog of the 2’-Deoxyguanosine adduct.

Technology Process of 1,N(2)-ethenodeoxyguanosine

There total 6 articles about 1,N(2)-ethenodeoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

linoleic acid (60-33-3,116745-32-5,26085-09-6,64080-88-2,7049-66-3,949900-18-9,60476-23-5,6144-28-1,67922-65-0,89718-18-3) + 2'-Deoxyguanosine (961-07-9) → (2E)-4-oxo-2-nonenal (103560-62-9) + 1,N2-etheno-2′-deoxyguanosine (108929-11-9)

Guidance literature:

With ferrous iron; NAD; 1,3-dinitropyrene; E_. coli nitroreductase; In phosphate buffer; at 37 ℃; for 1h; pH=7;

DOI:10.1002/tox.20253

Reference yield:

ethyl (9Z,12Z)-9,12-octadecadienoate (544-35-4) + 2'-Deoxyguanosine (961-07-9) → N2,3-ethenoguanine (62962-42-9) + 1,N2-etheno-2′-deoxyguanosine (108929-11-9) + 3H,5H,9H-imidazo[1,2-a]purin-9-one (56287-13-9)

Guidance literature:

With tert.-butylhydroperoxide; In methanol; at 50 ℃; for 72h; pH=7.4;

DOI:10.1021/tx0001124

Reference yield:

2-chloroethanal (107-20-0) + 2'-Deoxyguanosine (961-07-9) → 1,N2-etheno-2′-deoxyguanosine (108929-11-9)

Guidance literature:

With phosphate buffer; at 37 ℃; for 96h; pH=6.4;

DOI:10.1021/tx000004h

upstream raw materials:

2'-Deoxyguanosine

1-bromoacetone

3H,5H,9H-imidazo[1,2-a]purin-9-one

2'-Deoxycytidine

Downstream raw materials:

2'-Deoxyguanosine

3-(2-deoxy-β-D-erythropentofuranosyl)-6,7-dihydro-6,7-dihydroxyimidazo<1,2-a>purin-9(3H)-one

6-(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-ylamino)-hexanoic acid ethyl ester

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