(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichlorobenzyloxy)oxetan-3-yl)methanone trifluoroacetate

Base Information

Chemical Name:(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichlorobenzyloxy)oxetan-3-yl)methanone trifluoroacetate
CAS No.:1445983-58-3
Molecular Formula:C₂HF₃O₂*C₂₂H₂₂Cl₂N₂O₃
Molecular Weight:547.358
Hs Code.:

Synonyms:(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichlorobenzyloxy)oxetan-3-yl)methanone trifluoroacetate

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Chemical Property of (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichlorobenzyloxy)oxetan-3-yl)methanone trifluoroacetate

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Technology Process of (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichlorobenzyloxy)oxetan-3-yl)methanone trifluoroacetate

There total 11 articles about (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichlorobenzyloxy)oxetan-3-yl)methanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1224640-13-4
1-cyclopropyl-1,2,3,4-tetrahydro-quinoxaline

: 1445985-86-3
3-(2,5-dichlorobenzyloxy)oxetane-3-carboxylic acid

: 1445983-58-3
(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichlorobenzyloxy)oxetan-3-yl)methanone trifluoroacetate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 1224640-11-2
1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445983-58-3
(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichlorobenzyloxy)oxetan-3-yl)methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 4 h / 50 °C

3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h

With 1-hydroxy-7-aza-benzotriazole; borane-THF; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1224640-12-3
1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445983-58-3
(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichlorobenzyloxy)oxetan-3-yl)methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 4 h / 50 °C

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h

With 1-hydroxy-7-aza-benzotriazole; borane-THF; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;