2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenol

Base Information

Chemical Name:2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenol
CAS No.:1258001-26-1
Molecular Formula:C₁₃H₁₉FN₄O₂Si
Molecular Weight:310.403
Hs Code.:

Synonyms:2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenol

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Chemical Property of 2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenol

Chemical Property:

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Technology Process of 2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenol

There total 4 articles about 2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258001-28-3
5-(4-(benzyloxy)-3-fluorophenyl)-1H-tetrazole

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1258001-27-2
2-fluoro-4-(2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazol-5-yl)phenol

: 1258001-26-1
2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenol

Guidance literature:: 5-(4-(benzyloxy)-3-fluorophenyl)-1H-tetrazole; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.25h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; for 16h;

With formic acid; palladium; In tetrahydrofuran; ethanol; at 20 ℃; for 4h;

Reference yield:

: 1258001-30-7
5-(4-(benzyloxy)-3-fluorophenyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazole

: 1258001-29-4
5-(4-(benzyloxy)-3-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazole

: 1258001-27-2
2-fluoro-4-(2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazol-5-yl)phenol

: 1258001-26-1
2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenol

Guidance literature:: With formic acid; palladium; In tetrahydrofuran; ethanol; at 20 ℃; for 4h;

Reference yield:

: 1044067-62-0
4-(benzyloxy)-3-fluorobenzonitrile

: 1258001-27-2
2-fluoro-4-(2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazol-5-yl)phenol

: 1258001-26-1
2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 18 h / 110 °C

1.2: 20 °C / pH 3

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

2.2: 16 h / 20 °C

2.3: 4 h / 20 °C

With sodium azide; sodium hydride; ammonium chloride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;