5-(4-(benzyloxy)-3-fluorophenyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazole

Base Information

Chemical Name:5-(4-(benzyloxy)-3-fluorophenyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazole
CAS No.:1258001-30-7
Molecular Formula:C₂₀H₂₅FN₄O₂Si
Molecular Weight:400.528
Hs Code.:

Synonyms:5-(4-(benzyloxy)-3-fluorophenyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazole

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Chemical Property of 5-(4-(benzyloxy)-3-fluorophenyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazole

Chemical Property:

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Technology Process of 5-(4-(benzyloxy)-3-fluorophenyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazole

There total 5 articles about 5-(4-(benzyloxy)-3-fluorophenyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258001-28-3
5-(4-(benzyloxy)-3-fluorophenyl)-1H-tetrazole

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1258001-30-7
5-(4-(benzyloxy)-3-fluorophenyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazole

: 1258001-29-4
5-(4-(benzyloxy)-3-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazole

Guidance literature:: 5-(4-(benzyloxy)-3-fluorophenyl)-1H-tetrazole; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.25h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; for 16h;

Reference yield:

: 1258001-28-3
5-(4-(benzyloxy)-3-fluorophenyl)-1H-tetrazole

: 1258001-28-3
5-(4-(benzyloxy)-3-fluorophenyl)-2H-tetrazole

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1258001-30-7
5-(4-(benzyloxy)-3-fluorophenyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazole

: 1258001-29-4
5-(4-(benzyloxy)-3-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazole

Guidance literature:: 5-(4-(benzyloxy)-3-fluorophenyl)-1H-tetrazole; 5-(4-(benzyloxy)-3-fluorophenyl)-2H-tetrazole; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.25h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 100-39-0
benzyl bromide

: 1258001-30-7
5-(4-(benzyloxy)-3-fluorophenyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazole

: 1258001-29-4
5-(4-(benzyloxy)-3-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 0.17 h

1.2: 70 h / 20 °C

2.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 18 h / 110 °C

2.2: 20 °C / pH 3

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

3.2: 16 h / 20 °C

With sodium azide; sodium hydride; potassium carbonate; ammonium chloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oil;