isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
CAS No.:1258001-76-1
Molecular Formula:C₂₇H₃₇FN₈O₄Si
Molecular Weight:584.726
Hs Code.:

isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Synonyms:isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Chemical Property of isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Technology Process of isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

There total 9 articles about isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1258001-12-5
isopropyl 4-[5-cyano-4-(hydroxymethyl)-1H-pyrazol-1-yl]piperidine-1-carboxylate

: 1258001-27-2
2-fluoro-4-(2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazol-5-yl)phenol

: 1258001-26-1
2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenol

: 1258001-77-2
isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1258001-76-1
isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 1258001-28-3
5-(4-(benzyloxy)-3-fluorophenyl)-1H-tetrazole

: 1258001-12-5
isopropyl 4-[5-cyano-4-(hydroxymethyl)-1H-pyrazol-1-yl]piperidine-1-carboxylate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1258001-77-2
isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1258001-76-1
isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: 5-(4-(benzyloxy)-3-fluorophenyl)-1H-tetrazole; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.25h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; for 16h;

isopropyl 4-[5-cyano-4-(hydroxymethyl)-1H-pyrazol-1-yl]piperidine-1-carboxylate;

Reference yield:

: 1258001-07-8
isopropyl 4-[5-bromo-4-(ethoxycarbonyl)-1H-pyrazol-1-yl]piperidine-1-carboxylate

: 1258001-77-2
isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-((2-(trimethylsilyl)ethoxy)methyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1258001-76-1
isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 25 h / 0 - 20 °C / Reflux

1.2: 0.17 h / 0 - 20 °C

2.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 1 h / 120 °C / Inert atmosphere; microwave reactor

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

3.2: 16 h / 20 °C

With dimethylsulfide borane complex; sodium hydride; zinc; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ISOPROPYLAMIDE; mineral oil;