2-(4-chlorophenyl)-4-(3-piperidinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide

Base Information

Chemical Name:2-(4-chlorophenyl)-4-(3-piperidinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide
CAS No.:1174717-18-0
Molecular Formula:C₁₉H₁₉ClN₄OS
Molecular Weight:386.905
Hs Code.:

Synonyms:2-(4-chlorophenyl)-4-(3-piperidinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide

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Chemical Property of 2-(4-chlorophenyl)-4-(3-piperidinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide

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Technology Process of 2-(4-chlorophenyl)-4-(3-piperidinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide

There total 9 articles about 2-(4-chlorophenyl)-4-(3-piperidinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100523-84-0
2-bromothiophene-4-carboxylic acid

: 1174717-18-0
2-(4-chlorophenyl)-4-(3-piperidinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid / Reflux

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 3 h / Reflux

3.1: tetrahydrofuran / 20 °C

3.2: -78 °C / Inert atmosphere

3.3: pH 3

4.1: hydrazine hydrate / ethanol / 20 - 70 °C

5.1: trichlorophosphate / 3 h / 95 °C

6.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

6.2: 90 °C

7.1: ammonium hydroxide / 1,4-dioxane / 80 °C / sealed tube

8.1: hydrogenchloride / water; ethyl acetate / 1 h / 30 °C

9.1: sodium carbonate / water / 0.5 h / pH 9 - 10

With hydrogenchloride; ammonium hydroxide; hydrazine hydrate; sulfuric acid; sodium carbonate; 9-bora-bicyclo[3.3.1]nonane; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; ethyl acetate; toluene;

Reference yield:

: 1174718-02-5
2-(4-chlorophenyl)-4-(3-piperidinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide hydrochloride

: 1174717-18-0
2-(4-chlorophenyl)-4-(3-piperidinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide

Guidance literature:: With sodium carbonate; In water; pH=9 - 10;

Reference yield:

: 170355-38-1
5-bromo-3-thiophenecarboxylic acid ethyl ester

: 1174717-18-0
2-(4-chlorophenyl)-4-(3-piperidinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 3 h / Reflux

2.1: tetrahydrofuran / 20 °C

2.2: -78 °C / Inert atmosphere

2.3: pH 3

3.1: hydrazine hydrate / ethanol / 20 - 70 °C

4.1: trichlorophosphate / 3 h / 95 °C

5.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

5.2: 90 °C

6.1: ammonium hydroxide / 1,4-dioxane / 80 °C / sealed tube

7.1: hydrogenchloride / water; ethyl acetate / 1 h / 30 °C

8.1: sodium carbonate / water / 0.5 h / pH 9 - 10

With hydrogenchloride; ammonium hydroxide; hydrazine hydrate; sodium carbonate; 9-bora-bicyclo[3.3.1]nonane; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; ethyl acetate; toluene;