2-(4-(1-(4-methoxybenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

Base Information

• Chemical Name: 2-(4-(1-(4-methoxybenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide
• CAS No.: 949559-62-0
• Molecular Formula: C₃₂H₂₃F₂IN₆O₃
• Molecular Weight: 704.474

Synonyms:2-(4-(1-(4-methoxybenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

Chemical Property of 2-(4-(1-(4-methoxybenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

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Technology Process of 2-(4-(1-(4-methoxybenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

There total 1 articles about 2-(4-(1-(4-methoxybenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3 ,4-b]pyridine (949558-31-0) + 2-(3-fluoro-4-hydroxyphenylamino)-N-(4-fluorophenyl)nicotinamide (949559-61-9) → 2-(4-(1-(4-methoxybenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide (949559-62-0)

Guidance literature:

With bromobenzene; caesium carbonate; at 160 ℃; for 18h;

Reference yield: 25.0%

2-(4-(1-(4-methoxybenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide (949559-62-0) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-((4-(2-fluoro-4-(3-(4-fluorophenylcarbamoyl)pyridin-2-ylamino)phenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yloxy)methyl)piperidine-1-carboxylate (1129458-79-2)

Guidance literature:

With 40% potassium fluoride/alumina; copper(l) iodide; 1,10-Phenanthroline; In toluene; at 110 ℃; for 96h;

upstream raw materials:

4-chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3 ,4-b]pyridine

2-(3-fluoro-4-hydroxyphenylamino)-N-(4-fluorophenyl)nicotinamide

Downstream raw materials:

tert-butyl 4-((4-(2-fluoro-4-(3-(4-fluorophenylcarbamoyl)pyridin-2-ylamino)phenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yloxy)methyl)piperidine-1-carboxylate

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