Technology Process of methyl 2-fluoro-3-(2-fluoro-3-(2-fluoro-3-nitro-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzoate
There total 12 articles about methyl 2-fluoro-3-(2-fluoro-3-(2-fluoro-3-nitro-5-octylbenzamido)-5-octylbenzamido)-5-octylbenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; toluene / 30 h / 90 °C / Inert atmosphere
2.1: iron; acetic acid / ethanol / 2 h / Reflux
3.1: thionyl chloride / 4 h / Reflux
3.2: 4 h
4.1: iron; acetic acid / ethanol / 2 h / Reflux
5.1: thionyl chloride / 4 h / Reflux
5.2: 4 h
With
tetrakis(triphenylphosphine) palladium(0); thionyl chloride; iron; potassium carbonate; acetic acid;
In
ethanol; water; toluene;
DOI:10.1021/ol201361f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-Bromosuccinimide; sulfuric acid; trifluoroacetic acid / 6 h / 45 °C
2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; toluene / 30 h / 90 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 2 h / Reflux
4.1: thionyl chloride / 4 h / Reflux
4.2: 4 h
5.1: iron; acetic acid / ethanol / 2 h / Reflux
6.1: thionyl chloride / 4 h / Reflux
6.2: 4 h
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; sulfuric acid; iron; potassium carbonate; acetic acid; trifluoroacetic acid;
In
ethanol; water; toluene;
DOI:10.1021/ol201361f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; toluene / 30 h / 90 °C / Inert atmosphere
2.1: iron; acetic acid / ethanol / 2 h / Reflux
3.1: thionyl chloride / 4 h / Reflux
3.2: 4 h
4.1: iron; acetic acid / ethanol / 2 h / Reflux
5.1: thionyl chloride / 4 h / Reflux
5.2: 4 h
With
tetrakis(triphenylphosphine) palladium(0); thionyl chloride; iron; potassium carbonate; acetic acid;
In
ethanol; water; toluene;
DOI:10.1021/ol201361f
