tert-butyl N-[(1S)-5-[[(2S)-2,6-bis(tert-butoxycarbonylamino)hexanoyl]amino]-1-[[4-[2-(2,3,5,6-tetrafluoro-4-pyridyl)ethynyl]phenyl]carbamoyl]pentyl]carbamate

Base Information

Chemical Name:tert-butyl N-[(1S)-5-[[(2S)-2,6-bis(tert-butoxycarbonylamino)hexanoyl]amino]-1-[[4-[2-(2,3,5,6-tetrafluoro-4-pyridyl)ethynyl]phenyl]carbamoyl]pentyl]carbamate
CAS No.:1350811-88-9
Molecular Formula:C₄₀H₅₄F₄N₆O₈
Molecular Weight:822.898
Hs Code.:

tert-butyl N-[(1S)-5-[[(2S)-2,6-bis(tert-butoxycarbonylamino)hexanoyl]amino]-1-[[4-[2-(2,3,5,6-tetrafluoro-4-pyridyl)ethynyl]phenyl]carbamoyl]pentyl]carbamate

Synonyms:tert-butyl N-[(1S)-5-[[(2S)-2,6-bis(tert-butoxycarbonylamino)hexanoyl]amino]-1-[[4-[2-(2,3,5,6-tetrafluoro-4-pyridyl)ethynyl]phenyl]carbamoyl]pentyl]carbamate

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Chemical Property of tert-butyl N-[(1S)-5-[[(2S)-2,6-bis(tert-butoxycarbonylamino)hexanoyl]amino]-1-[[4-[2-(2,3,5,6-tetrafluoro-4-pyridyl)ethynyl]phenyl]carbamoyl]pentyl]carbamate

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Technology Process of tert-butyl N-[(1S)-5-[[(2S)-2,6-bis(tert-butoxycarbonylamino)hexanoyl]amino]-1-[[4-[2-(2,3,5,6-tetrafluoro-4-pyridyl)ethynyl]phenyl]carbamoyl]pentyl]carbamate

There total 4 articles about tert-butyl N-[(1S)-5-[[(2S)-2,6-bis(tert-butoxycarbonylamino)hexanoyl]amino]-1-[[4-[2-(2,3,5,6-tetrafluoro-4-pyridyl)ethynyl]phenyl]carbamoyl]pentyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55757-60-3
N-α-(tert-butoxycarbonyl)-L-lysine methyl ester

: 1350811-88-9
tert-butyl N-[(1S)-5-[[(2S)-2,6-bis(tert-butoxycarbonylamino)hexanoyl]amino]-1-[[4-[2-(2,3,5,6-tetrafluoro-4-pyridyl)ethynyl]phenyl]carbamoyl]pentyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C

1.2: 12 h / 20 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.25 h / 0 °C

3.2: 12 h / 20 °C

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm2010282

Reference yield:

: 1185249-12-0
4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)aniline

: 51513-72-5
(S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid

: 1350811-88-9
tert-butyl N-[(1S)-5-[[(2S)-2,6-bis(tert-butoxycarbonylamino)hexanoyl]amino]-1-[[4-[2-(2,3,5,6-tetrafluoro-4-pyridyl)ethynyl]phenyl]carbamoyl]pentyl]carbamate

Guidance literature:: (S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.25h;

4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)aniline; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jm2010282

Reference yield:

: 675601-23-7
(S,2S,2'S)-N,N'-(3,3'-(2-(4-(4-(3-(3,5-diamino-6-chloropyrazin-2-carbonyl)guanidino)butyl)phenoxy)ethylazanediyl)bis(propane-3,1-diyl))bis(2-amino-6-((S)-2,6-diaminohexanamido)hexanamide)

: 1350811-88-9
tert-butyl N-[(1S)-5-[[(2S)-2,6-bis(tert-butoxycarbonylamino)hexanoyl]amino]-1-[[4-[2-(2,3,5,6-tetrafluoro-4-pyridyl)ethynyl]phenyl]carbamoyl]pentyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.25 h / 0 °C

2.2: 12 h / 20 °C

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm2010282