(S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid

Base Information

• Chemical Name: (S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid
• CAS No.: 51513-72-5
• Molecular Formula: C₂₇H₅₀N₄O₉
• Molecular Weight: 574.715
• Mol file: 51513-72-5.mol

Synonyms:(S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid

Chemical Property of (S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid

There total 1 articles about (S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-α-(tert-butoxycarbonyl)-L-lysine methyl ester (55757-60-3) → (S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid (51513-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C

1.2: 12 h / 20 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jm2010282

Reference yield: 75.0%

benzyl 4-(4-(2-(bis(3-aminopropyl)amino)ethoxy)phenyl)butylcarbamate trihydrochloride + (S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid (51513-72-5) → C80H136N12O19

Guidance literature:

With 4-methyl-morpholine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 73.0%

(R)-2-amino-N-(2-(3,4-bis(mercaptomethyl)phenoxy)ethyl)-6-guanidinohexanamide hydrochloride + (S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid (51513-72-5) → C70H120N10O20S2

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

upstream raw materials:

N-α-(tert-butoxycarbonyl)-L-lysine methyl ester

Downstream raw materials:

[5-(5-{4-[6-(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-2-tert-butoxycarbonylamino-hexanoylamino]-phenylcarbamoyl}-5-tert-butoxycarbonylamino-pentylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester

tert-butyl N-[(1S)-5-[[(2S)-2,6-bis(tert-butoxycarbonylamino)hexanoyl]amino]-1-[[3,4-bis[2-(2,3,5,6-tetrafluoro-4-pyridyl)ethynyl]phenyl]carbamoyl]pentyl]carbamate

tert-butyl N-[(1S)-5-[[(2S)-2,6-bis(tert-butoxycarbonylamino)hexanoyl]amino]-1-[[4-[2-(2,3,5,6-tetrafluoro-4-pyridyl)ethynyl]phenyl]carbamoyl]pentyl]carbamate