(2S,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one

Base Information

• Chemical Name: (2S,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one
• CAS No.: 1428736-54-2
• Molecular Formula: C₁₉H₂₃N₃O₃
• Molecular Weight: 341.41
• Mol file: 1428736-54-2.mol

Synonyms:(2S,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one

Chemical Property of (2S,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one

There total 5 articles about (2S,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

2-acetylpyridine (1122-62-9) + (S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropionamide (109522-07-8) → (2R,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one (1428736-53-1) + (2S,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one (1428736-54-2)

Guidance literature:

With toluene-4-sulfonic acid; In 1,2-dichloro-benzene; at 140 ℃; for 2h;

DOI:10.1016/j.tetasy.2013.02.007

Reference yield:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanoic acid (132970-18-4) → (2R,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one (1428736-53-1) + (2S,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one (1428736-54-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; chloroformic acid ethyl ester / dichloromethane / 0.12 h / 0 °C

1.2: 96 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 8 h / Reflux

3.1: toluene-4-sulfonic acid / 1,2-dichloro-benzene / 2 h / 140 °C

With chloroformic acid ethyl ester; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-benzene;

DOI:10.1016/j.tetasy.2013.02.007

Reference yield:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanamide (1428736-38-2) → (2R,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one (1428736-53-1) + (2S,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one (1428736-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 8 h / Reflux

2: toluene-4-sulfonic acid / 1,2-dichloro-benzene / 2 h / 140 °C

With toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-benzene;

DOI:10.1016/j.tetasy.2013.02.007

upstream raw materials:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanoic acid

(2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanamide

2-acetylpyridine

(S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropionamide