6-(4-fluorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

Base Information

• Chemical Name: 6-(4-fluorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
• CAS No.: 131364-75-5
• Molecular Formula: C₁₁H₆FN₃OS
• Molecular Weight: 247.253
• Mol file: 131364-75-5.mol

Synonyms:6-(4-fluorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

Chemical Property of 6-(4-fluorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-fluorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

There total 2 articles about 6-(4-fluorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-fluorobenzaldehyde (459-57-4) + thiourea (17356-08-0) + ethyl 2-cyanoacetate (105-56-6) → 6-(4-fluorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (131364-75-5)

Guidance literature:

With potassium carbonate; In ethanol; for 6h; Reflux;

DOI:10.1016/j.ejmech.2010.11.022

Reference yield:

→ 6-(4-fluorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (131364-75-5)

Guidance literature:

With potassium carbonate; In ethanol; at 20 ℃;

Reference yield: 95.0%

6-(4-fluorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (131364-75-5) + ethylene dibromide (106-93-4) → 2,3-Dihydro-7-(4-fluorophenyl)-5-oxothiazolo<3,2-a>pyrimidine-6-carbonitrile (131364-55-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 3h; Heating;

DOI:10.1002/ardp.19903231103

upstream raw materials:

4-fluorobenzaldehyde

thiourea

ethyl 2-cyanoacetate

Downstream raw materials:

2,3-Dihydro-7-(4-fluorophenyl)-5-oxothiazolo<3,2-a>pyrimidine-6-carbonitrile

8-(4-Fluorophenyl)-6-oxo-2,3,4-trihydropyrimido<2,1-b>thiazine-7-carbonitrile

2-Cyanomethyl-3,4-dihydro-6-(4-fluorophenyl)-4-oxopyrimidine-5-carbonitrile

4-(4-fluorophenyl)-1,6-dihydro-1-methyl-2-(methylthio)-6-oxopyrimidine-5-carbonitrile