Technology Process of 1-(2,3-dihydroxy-propyl)-cyclohexane-1,3-dicarboxylic acid diethyl ester
There total 3 articles about 1-(2,3-dihydroxy-propyl)-cyclohexane-1,3-dicarboxylic acid diethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Quinuclidine; potassium osmate(VI) dihydrate; potassium hexacyanoferrate (III); potassium carbonate;
In
water; tert-butyl alcohol;
at 18 - 25 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 1.5 h / -78 - 0 °C / Inert atmosphere
1.2: -78 - 25 °C / Inert atmosphere
2.1: potassium carbonate; Quinuclidine; potassium osmate(VI) dihydrate; potassium hexacyanoferrate (III) / water; tert-butyl alcohol / 18 - 25 °C / Inert atmosphere
With
Quinuclidine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium osmate(VI) dihydrate; potassium hexacyanoferrate (III); n-butyllithium; potassium carbonate;
In
tetrahydrofuran; water; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / 5 h / 18 - 25 °C / Inert atmosphere; Reflux
2.1: n-butyllithium; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 1.5 h / -78 - 0 °C / Inert atmosphere
2.2: -78 - 25 °C / Inert atmosphere
3.1: potassium carbonate; Quinuclidine; potassium osmate(VI) dihydrate; potassium hexacyanoferrate (III) / water; tert-butyl alcohol / 18 - 25 °C / Inert atmosphere
With
Quinuclidine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium osmate(VI) dihydrate; potassium hexacyanoferrate (III); n-butyllithium; sulfuric acid; potassium carbonate;
In
tetrahydrofuran; water; tert-butyl alcohol;
