C₂₁H₁₉BF₂N₆

Base Information

• Chemical Name: C₂₁H₁₉BF₂N₆
• CAS No.: 1446521-19-2
• Molecular Formula: C₂₁H₁₉BF₂N₆
• Molecular Weight: 404.23
• Mol file: 1446521-19-2.mol

Synonyms:C₂₁H₁₉BF₂N₆

Chemical Property of C₂₁H₁₉BF₂N₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₉BF₂N₆

There total 4 articles about C₂₁H₁₉BF₂N₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.4%

3-(5,5-difluoro-1,3,7,9-tetramethyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2’,1’-f][1,3,2]diazaborinin-10-yl)benzonitrile (1446521-18-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) + acetonitrile (75-05-8,26809-02-9) → C21H19BF2N6 (1446521-19-2) + 5,5-difluoro-1,3,7,9-tetramethyl-10-(3-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)-5H-4λ4,5λ4-dipyrrolo[1,2-c:2’,1’-f][1,3,2]diazaborinine (1446521-23-8)

Guidance literature:

3-(5,5-difluoro-1,3,7,9-tetramethyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2’,1’-f][1,3,2]diazaborinin-10-yl)benzonitrile; N,N-dimethyl-formamide; acetonitrile; With zinc trifluoromethanesulfonate; hydrazine; at 60 ℃; Inert atmosphere; Sealed tube;

With hydrogenchloride; sodium nitrite; In water; pH=3; Inert atmosphere;

DOI:10.1002/anie.201301100

Reference yield: 3.0%

3-(5,5-difluoro-1,3,7,9-tetramethyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2’,1’-f][1,3,2]diazaborinin-10-yl)benzonitrile (1446521-18-1) + formamidine acetic acid (3473-63-0) → C21H19BF2N6 (1446521-19-2)

Guidance literature:

3-(5,5-difluoro-1,3,7,9-tetramethyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2’,1’-f][1,3,2]diazaborinin-10-yl)benzonitrile; formamidine acetic acid; With zinc trifluoromethanesulfonate; hydrazine hydrate; In N,N-dimethyl-formamide; at 60 ℃; for 24h; Microwave irradiation; Sealed tube;

With hydrogenchloride; sodium nitrite; In water; N,N-dimethyl-formamide; at 20 ℃; Microwave irradiation; Sealed tube;

DOI:10.1002/chem.201902907

Reference yield:

2,4-dimethyl-1H-pyrrole (625-82-1) + 3-Cyanobenzaldehyde (24964-64-5) → C21H19BF2N6 (1446521-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: zinc trifluoromethanesulfonate; hydrazine hydrate / N,N-dimethyl-formamide / 24 h / 60 °C / Microwave irradiation; Sealed tube

2.2: 20 °C / Microwave irradiation; Sealed tube

With zinc trifluoromethanesulfonate; hydrazine hydrate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.201902907

upstream raw materials:

3-(5,5-difluoro-1,3,7,9-tetramethyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2’,1’-f][1,3,2]diazaborinin-10-yl)benzonitrile

N,N-dimethyl-formamide

acetonitrile

2,4-dimethyl-1H-pyrrole