Technology Process of 5-cyclopropyl-2-(4-cyclopropylphenyl)-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-N-methyl-2H-indazole-3-carboxamide
There total 9 articles about 5-cyclopropyl-2-(4-cyclopropylphenyl)-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-N-methyl-2H-indazole-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate;
palladium diacetate; tricyclohexylphosphine;
In
water; toluene;
at 100 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: nitric acid; sulfuric acid / 0.42 h / cooling with ice
2.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice
3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 6 h / Inert atmosphere; Reflux
4.1: acetic acid / 60 °C
4.2: 0.08 h / 60 °C
5.1: phosphorus trichloride / chloroform / 1 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 15 h / 90 °C
7.1: pyridine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C
8.1: water; ammonium chloride; iron / ethanol / 1.5 h / 80 °C
9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C
10.1: potassium carbonate / acetonitrile / 16 h / 80 °C
11.1: potassium phosphate / tricyclohexylphosphine; palladium diacetate / toluene; water / 2 h / 100 °C / Inert atmosphere
With
pyridine; potassium phosphate; sulfuric acid; water; nitric acid; iron; sodium carbonate; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; phosphorus trichloride;
tetrakis(triphenylphosphine) palladium(0); palladium diacetate; tricyclohexylphosphine;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene; acetonitrile;
3.1: Suzuki Coupling / 11.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice
2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 6 h / Inert atmosphere; Reflux
3.1: acetic acid / 60 °C
3.2: 0.08 h / 60 °C
4.1: phosphorus trichloride / chloroform / 1 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 15 h / 90 °C
6.1: pyridine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C
7.1: water; ammonium chloride; iron / ethanol / 1.5 h / 80 °C
8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C
9.1: potassium carbonate / acetonitrile / 16 h / 80 °C
10.1: potassium phosphate / tricyclohexylphosphine; palladium diacetate / toluene; water / 2 h / 100 °C / Inert atmosphere
With
pyridine; potassium phosphate; sulfuric acid; water; nitric acid; iron; sodium carbonate; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; phosphorus trichloride;
tetrakis(triphenylphosphine) palladium(0); palladium diacetate; tricyclohexylphosphine;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene; acetonitrile;
2.1: Suzuki Coupling / 10.1: Suzuki Coupling;
![2-(4-bromophenyl)-5-cyclopropyl-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-N-methyl-2H-indazole-3-carboxamide](/Databaselist/images/loading.webp)
