1-[(1R,2S)-2-(2,4-Difluoro-phenyl)-2-hydroxy-3-(isopropoxy-dimethyl-silanyl)-1-methyl-propyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one

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Chemical Name:1-[(1R,2S)-2-(2,4-Difluoro-phenyl)-2-hydroxy-3-(isopropoxy-dimethyl-silanyl)-1-methyl-propyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one
CAS No.:325988-94-1
Molecular Formula:C₂₅H₃₀F₂N₆O₃Si
Molecular Weight:528.634
Hs Code.:

Synonyms:1-[(1R,2S)-2-(2,4-Difluoro-phenyl)-2-hydroxy-3-(isopropoxy-dimethyl-silanyl)-1-methyl-propyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one

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Chemical Property of 1-[(1R,2S)-2-(2,4-Difluoro-phenyl)-2-hydroxy-3-(isopropoxy-dimethyl-silanyl)-1-methyl-propyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one

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Technology Process of 1-[(1R,2S)-2-(2,4-Difluoro-phenyl)-2-hydroxy-3-(isopropoxy-dimethyl-silanyl)-1-methyl-propyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one

There total 6 articles about 1-[(1R,2S)-2-(2,4-Difluoro-phenyl)-2-hydroxy-3-(isopropoxy-dimethyl-silanyl)-1-methyl-propyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 122588-50-5
(dimethylisopropoxysilyl)methylmagnesium chloride

: 325988-93-0
1-[(R)-2-(2,4-Difluoro-phenyl)-1-methyl-2-oxo-ethyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one

: 325988-94-1
1-[(1R,2S)-2-(2,4-Difluoro-phenyl)-2-hydroxy-3-(isopropoxy-dimethyl-silanyl)-1-methyl-propyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one

Guidance literature:: In tetrahydrofuran; at -5 ℃; for 3h;
DOI:10.1248/cpb.48.1935

Reference yield:

: 14213-13-9
4-tetrazol-1-yl-phenylamine

: 325988-94-1
1-[(1R,2S)-2-(2,4-Difluoro-phenyl)-2-hydroxy-3-(isopropoxy-dimethyl-silanyl)-1-methyl-propyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 88 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2.1: 99 percent / pyridine / 3 h / 50 °C

3.1: 79 percent / aq. HCl / methanol / 14 h / 20 °C

4.1: NaH / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

4.2: 34 percent / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 0.5 h / -20 °C

5.1: 20 percent / tetrahydrofuran / 3 h / -5 °C

With pyridine; hydrogenchloride; sodium hydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;
DOI:10.1248/cpb.48.1935

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 325988-94-1
1-[(1R,2S)-2-(2,4-Difluoro-phenyl)-2-hydroxy-3-(isopropoxy-dimethyl-silanyl)-1-methyl-propyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: K₂CO₃ / dimethylformamide / 10 h / 70 - 75 °C

1.2: 44 percent / N₂H₄*H₂O; FeCl₃; activated carbon / tetrahydrofuran; methanol / 10 h / 50 °C

2.1: 88 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 99 percent / pyridine / 3 h / 50 °C

4.1: 79 percent / aq. HCl / methanol / 14 h / 20 °C

5.1: NaH / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

5.2: 34 percent / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 0.5 h / -20 °C

6.1: 20 percent / tetrahydrofuran / 3 h / -5 °C

With pyridine; hydrogenchloride; sodium hydride; potassium carbonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.48.1935