methyl 2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethylsulfonyl)benzoate

Base Information

• Chemical Name: methyl 2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethylsulfonyl)benzoate
• CAS No.: 1395896-38-4
• Molecular Formula: C₁₄H₁₅N₃O₆S
• Molecular Weight: 353.356
• Mol file: 1395896-38-4.mol

Synonyms:methyl 2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethylsulfonyl)benzoate

Chemical Property of methyl 2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethylsulfonyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethylsulfonyl)benzoate

There total 3 articles about methyl 2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethylsulfonyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

methyl 2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethylthio)benzoate (1395896-36-2) → methyl 2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethylsulfonyl)benzoate (1395896-38-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2012.06.083

Reference yield:

metronidazole (443-48-1) → methyl 2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethylsulfonyl)benzoate (1395896-38-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / chloroform / 12 h / 20 °C

2.1: potassium carbonate / acetonitrile / 0.25 h / 20 °C

2.2: 24 h / Reflux

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

With thionyl chloride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform; acetonitrile;

DOI:10.1016/j.bmcl.2012.06.083

Reference yield:

1-(2-chloroethyl)-2-methyl-5-nitro-1H-imidazole hydrochloride (1049762-81-3) → methyl 2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethylsulfonyl)benzoate (1395896-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 0.25 h / 20 °C

1.2: 24 h / Reflux

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2012.06.083

upstream raw materials:

methyl 2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethylthio)benzoate

metronidazole

1-(2-chloroethyl)-2-methyl-5-nitro-1H-imidazole hydrochloride