4-(4-chlorophenyl)-1-{3-[1-(tetrahydrothiophen-3-yl)azetidin-3-yl]-1H-indol-6-yl}-1H-pyridin-2-one

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Chemical Name:4-(4-chlorophenyl)-1-{3-[1-(tetrahydrothiophen-3-yl)azetidin-3-yl]-1H-indol-6-yl}-1H-pyridin-2-one
CAS No.:1187744-02-0
Molecular Formula:C₂₆H₂₄ClN₃OS
Molecular Weight:462.015
Hs Code.:

Synonyms:4-(4-chlorophenyl)-1-{3-[1-(tetrahydrothiophen-3-yl)azetidin-3-yl]-1H-indol-6-yl}-1H-pyridin-2-one

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Chemical Property of 4-(4-chlorophenyl)-1-{3-[1-(tetrahydrothiophen-3-yl)azetidin-3-yl]-1H-indol-6-yl}-1H-pyridin-2-one

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Technology Process of 4-(4-chlorophenyl)-1-{3-[1-(tetrahydrothiophen-3-yl)azetidin-3-yl]-1H-indol-6-yl}-1H-pyridin-2-one

There total 8 articles about 4-(4-chlorophenyl)-1-{3-[1-(tetrahydrothiophen-3-yl)azetidin-3-yl]-1H-indol-6-yl}-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1003-04-9
Tetrahydrothiophen-3-one

: 1-(3-azetidin-3-yl-1H-indol-6-yl)-4-(4-chlorophenyl)-1H-pyridin-2-one dihydrochloride

: 1187744-02-0
4-(4-chlorophenyl)-1-{3-[1-(tetrahydrothiophen-3-yl)azetidin-3-yl]-1H-indol-6-yl}-1H-pyridin-2-one

Guidance literature:: Tetrahydrothiophen-3-one; 1-(3-azetidin-3-yl-1H-indol-6-yl)-4-(4-chlorophenyl)-1H-pyridin-2-one dihydrochloride; With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 0.0833333h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 4h;

Reference yield:

3-(6-bromo-1H-indol-3-yl)-azetidine-1-carboxylic acid tert-butyl ester: 1187744-20-2
3-(6-bromo-1H-indol-3-yl)-azetidine-1-carboxylic acid tert-butyl ester

: 1187744-02-0
4-(4-chlorophenyl)-1-{3-[1-(tetrahydrothiophen-3-yl)azetidin-3-yl]-1H-indol-6-yl}-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; cis-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / dichloromethane / 90 °C

2.1: hydrogenchloride / diethyl ether; dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.08 h / 20 °C

3.2: 4 h / 20 °C

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; cis-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide; In diethyl ether; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 128071-98-7
4-bromo-2-fluoropyridine

: 1187744-02-0
4-(4-chlorophenyl)-1-{3-[1-(tetrahydrothiophen-3-yl)azetidin-3-yl]-1H-indol-6-yl}-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / 1,2-dimethoxyethane; water / 110 °C / Inert atmosphere

2.1: acetic acid / 16 h / 110 °C / Inert atmosphere

3.1: potassium carbonate; cis-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / dichloromethane / 90 °C

4.1: hydrogenchloride / diethyl ether; dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.08 h / 20 °C

5.2: 4 h / 20 °C

With hydrogenchloride; sodium carbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; cis-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane;