4-(4-Chlorophenyl)-2-hydroxypyridine

Base Information

Chemical Name:4-(4-Chlorophenyl)-2-hydroxypyridine
CAS No.:1173155-38-8
Molecular Formula:C₁₁H₈ClNO
Molecular Weight:205.644
Hs Code.:
DSSTox Substance ID:DTXSID20597149
Wikidata:Q82492644

Synonyms:1173155-38-8;4-(4-CHLOROPHENYL)-2-HYDROXYPYRIDINE;4-(4-Chlorophenyl)pyridin-2(1H)-one;4-(4-chlorophenyl)-1H-pyridin-2-one;4-(4-chloro-phenyl)-1h-pyridin-2-one;SCHEMBL3476831;DTXSID20597149;IVEDERMVYXTQFO-UHFFFAOYSA-N;MFCD18312074;4-(4-chlorophenyl)pyridine-2(1H)-one;DB-357466;4-(4-Chlorophenyl)-2-hydroxypyridine, 95%;A1-64722

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-Chlorophenyl)-2-hydroxypyridine

Chemical Property:

Boiling Point:417.9±45.0 °C(Predicted)
Density:1.287±0.06 g/cm3(Predicted)
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:205.0294416
Heavy Atom Count:14
Complexity:288

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CC(=O)NC=C2)Cl

Technology Process of 4-(4-Chlorophenyl)-2-hydroxypyridine

There total 4 articles about 4-(4-Chlorophenyl)-2-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 92929-25-4
4-(4-chlorophenyl)pyridine 1-oxide

4-(4-chloro-phenyl)-1H-pyridin-2-one: 1173155-38-8
4-(4-chloro-phenyl)-1H-pyridin-2-one

Guidance literature:: 4-(4-chlorophenyl)pyridine 1-oxide; With acetic anhydride; for 24h; Reflux;

With water; sodium hydroxide; In methanol; for 1h; Reflux;

Reference yield: 30.0%

: 1187744-24-6
4-(4-chlorophenyl)-2-fluoropyridine

4-(4-chloro-phenyl)-1H-pyridin-2-one: 1173155-38-8
4-(4-chloro-phenyl)-1H-pyridin-2-one

Guidance literature:: With acetic acid; at 110 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

4-(4-chloro-phenyl)-1H-pyridin-2-one: 1173155-38-8
4-(4-chloro-phenyl)-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 110 °C / Inert atmosphere

2: acetic acid / 6 h / 110 °C / Neat (no solvent); Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; acetic acid; In 1,2-dimethoxyethane; water; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.07.020