benzo[d]oxazol-2-yl(4-(trifluoromethyl)phenyl)methanone

Base Information

• Chemical Name: benzo[d]oxazol-2-yl(4-(trifluoromethyl)phenyl)methanone
• CAS No.: 1258498-80-4
• Molecular Formula: C₁₅H₈F₃NO₂
• Molecular Weight: 291.229

Synonyms:benzo[d]oxazol-2-yl(4-(trifluoromethyl)phenyl)methanone

Chemical Property of benzo[d]oxazol-2-yl(4-(trifluoromethyl)phenyl)methanone

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Technology Process of benzo[d]oxazol-2-yl(4-(trifluoromethyl)phenyl)methanone

There total 5 articles about benzo[d]oxazol-2-yl(4-(trifluoromethyl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzoxazole (273-53-0,29791-96-6) + 4-(trifluoromethyl)phenylglyoxylic acid (79478-02-7) → benzo[d]oxazol-2-yl(4-(trifluoromethyl)phenyl)methanone (1258498-80-4)

Guidance literature:

With nickel(II) perchlorate hexahydrate; silver carbonate; In benzene; at 170 ℃; for 24h;

DOI:10.1002/chem.201402516

Reference yield: 68.0%

1-(4-trifluoromethylphenyl)ethanone (709-63-7) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → benzo[d]oxazol-2-yl(4-(trifluoromethyl)phenyl)methanone (1258498-80-4)

Guidance literature:

With pyridine; sulfur; iron(II) chloride tetrahydrate; N-ethyl-N,N-diisopropylamine; at 80 - 100 ℃; for 16h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1039/d1ob00976a

Reference yield: 50.0%

2,2-dibromo-1-(4-(trifluoromethyl)phenyl)ethan-1-one (556110-56-6) + 2-amino-phenol (95-55-6) → benzo[d]oxazol-2-yl(4-(trifluoromethyl)phenyl)methanone (1258498-80-4)

Guidance literature:

With diethylamine; In N,N-dimethyl-formamide; at 90 ℃; for 5h;

DOI:10.1021/acs.joc.5b02093

upstream raw materials:

benzoxazole

carbon monoxide

4-Iodobenzotrifluoride

4-(trifluoromethyl)phenylglyoxylic acid

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