N-[(9H-fluoren-9-ylmethoxy)carbonyl]-norvalyl-sarcosine benzyl ester

Base Information

Chemical Name:N-[(9H-fluoren-9-ylmethoxy)carbonyl]-norvalyl-sarcosine benzyl ester
CAS No.:270085-10-4
Molecular Formula:C₃₀H₃₂N₂O₅
Molecular Weight:500.594
Hs Code.:

Synonyms:N-[(9H-fluoren-9-ylmethoxy)carbonyl]-norvalyl-sarcosine benzyl ester

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Chemical Property of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-norvalyl-sarcosine benzyl ester

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Technology Process of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-norvalyl-sarcosine benzyl ester

There total 2 articles about N-[(9H-fluoren-9-ylmethoxy)carbonyl]-norvalyl-sarcosine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 40298-32-6
methylglycine benzyl ester hydrochloride

: 135112-28-6
Fmoc-norvaline-OH

: 270085-10-4
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-norvalyl-sarcosine benzyl ester

Guidance literature:: With 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/S0040-4020(00)00657-8

Reference yield: 97.6%

: 135112-28-6
Fmoc-norvaline-OH

: benzyl 2-(methylamino)acetate trifluoroacetic acid salt

: 270085-10-4
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-norvalyl-sarcosine benzyl ester

Guidance literature:: With 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -10 - 20 ℃;
DOI:10.1021/jo991687c

Reference yield:

: 270085-10-4
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-norvalyl-sarcosine benzyl ester

: 781601-43-2
H-Nva-Sar-(Me)Leu-Val-(Me)Leu-Ala-OBzl

Guidance literature:: Multi-step reaction with 3 steps

1: 98.2 percent / H₂ / 15percent Pt black / methanol / 48 h

2: BEMT; DIEA / CH₂Cl₂ / -10 - 20 °C

3: HNEt₂ / acetonitrile / 0.67 h

With tinosorb S; hydrogen; diethylamine; N-ethyl-N,N-diisopropylamine; 15percent Pt black; In methanol; dichloromethane; acetonitrile; 1: Hydrogenolysis / 2: Condensation / 3: Fmoc-deprotection;
DOI:10.1021/jo991687c