Technology Process of H-Nva-Sar-(Me)Leu-Val-(Me)Leu-Ala-OBzl
There total 13 articles about H-Nva-Sar-(Me)Leu-Val-(Me)Leu-Ala-OBzl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 97.6 percent / BEP; DIEA / CH2Cl2 / -10 - 20 °C
2: 98.2 percent / H2 / 15percent Pt black / methanol / 48 h
3: BEMT; DIEA / CH2Cl2 / -10 - 20 °C
4: HNEt2 / acetonitrile / 0.67 h
With
tinosorb S; hydrogen; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; diethylamine; N-ethyl-N,N-diisopropylamine;
15percent Pt black;
In
methanol; dichloromethane; acetonitrile;
1: Condensation / 2: Hydrogenolysis / 3: Condensation / 4: Fmoc-deprotection;
DOI:10.1021/jo991687c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98.2 percent / H2 / 15percent Pt black / methanol / 48 h
2: BEMT; DIEA / CH2Cl2 / -10 - 20 °C
3: HNEt2 / acetonitrile / 0.67 h
With
tinosorb S; hydrogen; diethylamine; N-ethyl-N,N-diisopropylamine;
15percent Pt black;
In
methanol; dichloromethane; acetonitrile;
1: Hydrogenolysis / 2: Condensation / 3: Fmoc-deprotection;
DOI:10.1021/jo991687c
- Guidance literature:
-
With
diethylamine;
In
acetonitrile;
for 0.666667h;
DOI:10.1021/jo991687c
