5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]benzoic acid

Base Information

Chemical Name:5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]benzoic acid
CAS No.:1362819-91-7
Molecular Formula:C₂₃H₂₃N₃O₅
Molecular Weight:421.453
Hs Code.:

Synonyms:5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]benzoic acid

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Chemical Property of 5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]benzoic acid

Chemical Property:

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Technology Process of 5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]benzoic acid

There total 10 articles about 5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₂₉N₃O₅

: 1362819-91-7
5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]benzoic acid

Guidance literature:: C₃₀H₂₉N₃O₅; With water; lithium hydroxide; In tetrahydrofuran; for 18h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 50-85-1
2-hydroxy-p-toluic acid

: 1362819-91-7
5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]benzoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: thionyl chloride / 24 h / 50 °C

2: bromine / chloroform / 1 h / 0 °C

3: pyridine / 4 h

4: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C

5: water; calcium carbonate / 1,4-dioxane / 3 h / 150 °C

6: potassium carbonate / N,N-dimethyl-formamide / 21 h / 50 °C

7: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 0.75 h / 0 °C

8: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h

9: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.5 h / 130 °C / Microwave irradiation

10: water; lithium hydroxide / tetrahydrofuran / 18 h

With pyridine; sodium chlorite; potassium phosphate; N-Bromosuccinimide; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; aminosulfonic acid; water; bromine; potassium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; calcium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 4670-56-8
methyl 2-hydroxy-4-methylbenzoate

: 1362819-91-7
5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]benzoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: bromine / chloroform / 1 h / 0 °C

2: pyridine / 4 h

3: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C

4: water; calcium carbonate / 1,4-dioxane / 3 h / 150 °C

5: potassium carbonate / N,N-dimethyl-formamide / 21 h / 50 °C

6: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 0.75 h / 0 °C

7: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h

8: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.5 h / 130 °C / Microwave irradiation

9: water; lithium hydroxide / tetrahydrofuran / 18 h

With pyridine; sodium chlorite; potassium phosphate; N-Bromosuccinimide; 1-hydroxy-7-aza-benzotriazole; aminosulfonic acid; water; bromine; potassium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; calcium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;