2-[6-(4-pyrrolidin-1-ylmethylphenyl)pyrrolo[2,3-b]pyridin-1-yl]acetamide

Base Information

Chemical Name:2-[6-(4-pyrrolidin-1-ylmethylphenyl)pyrrolo[2,3-b]pyridin-1-yl]acetamide
CAS No.:1584679-77-5
Molecular Formula:C₂₀H₂₂N₄O
Molecular Weight:334.421
Hs Code.:

Synonyms:2-[6-(4-pyrrolidin-1-ylmethylphenyl)pyrrolo[2,3-b]pyridin-1-yl]acetamide

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Chemical Property of 2-[6-(4-pyrrolidin-1-ylmethylphenyl)pyrrolo[2,3-b]pyridin-1-yl]acetamide

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Technology Process of 2-[6-(4-pyrrolidin-1-ylmethylphenyl)pyrrolo[2,3-b]pyridin-1-yl]acetamide

There total 5 articles about 2-[6-(4-pyrrolidin-1-ylmethylphenyl)pyrrolo[2,3-b]pyridin-1-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1036991-20-4
[4-(pyrrolidin-1-ylmethyl)phenyl]boronic acid

: 1584678-97-6
2-(6-bromopyrrolo[2,3-b]pyridin-1-yl)acetamide

: 1584679-77-5
2-[6-(4-pyrrolidin-1-ylmethylphenyl)pyrrolo[2,3-b]pyridin-1-yl]acetamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 110 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.12.031

Reference yield:

: 271-63-6
7-Azaindole

: 1584679-77-5
2-[6-(4-pyrrolidin-1-ylmethylphenyl)pyrrolo[2,3-b]pyridin-1-yl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; 3-chloro-benzenecarboperoxoic acid / water / 20 °C

2.1: 1,1,1,3,3,3-hexamethyl-disilazane / toluene / 1 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / methanol / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

4.2: 3 h / 20 °C / Inert atmosphere

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / 1 h / 110 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; sodium hydrogencarbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; mineral oil; 5.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2013.12.031

Reference yield:

: 55052-24-9
1H-Pyrrolo[2,3-b]pyridine-7-oxide

: 1584679-77-5
2-[6-(4-pyrrolidin-1-ylmethylphenyl)pyrrolo[2,3-b]pyridin-1-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane / toluene / 1 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / 1 h / 110 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; sodium hydrogencarbonate; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; mineral oil; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2013.12.031