4-(pyrrolidin-1-ylMethyl)phenylboronic acid

Base Information

• Chemical Name: 4-(pyrrolidin-1-ylMethyl)phenylboronic acid
• CAS No.: 1036991-20-4
• Molecular Formula: C₁₁H₁₆BNO₂
• Molecular Weight: 205.065
• Hs Code.: 2933998090
• Mol file: 1036991-20-4.mol

Synonyms:[4-(pyrrolidin-1-ylmethyl)phenyl]boronic acid

Chemical Property of 4-(pyrrolidin-1-ylMethyl)phenylboronic acid

Chemical Property:

• Boiling Point: 353.0±44.0 °C(Predicted)
• PKA: 8.43±0.16(Predicted)
• Density: 1.16±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

[4-(Pyrrolidin-1-ylmethyl)phenyl]boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(pyrrolidin-1-ylMethyl)phenylboronic acid

There total 2 articles about 4-(pyrrolidin-1-ylMethyl)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

pyrrolidine (123-75-1) + 4-formylphenylboronic acid, (87199-17-5) → [4-(pyrrolidin-1-ylmethyl)phenyl]boronic acid (1036991-20-4)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃;

Reference yield:

pyrrolidine (123-75-1) + 4-bromomethylphenylboronic acid (68162-47-0) → [4-(pyrrolidin-1-ylmethyl)phenyl]boronic acid (1036991-20-4)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 65.62%

5-bromo-2-chloropyridine (53939-30-3) + [4-(pyrrolidin-1-ylmethyl)phenyl]boronic acid (1036991-20-4) → 2-chloro-5-(4-(pyrrolidin-1-ylmethyl)phenyl)pyridine

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 4h; Inert atmosphere;

upstream raw materials:

pyrrolidine

4-bromomethylphenylboronic acid

4-formylphenylboronic acid,

Downstream raw materials:

6-(4-pyrrolidin-1ylmethylphenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

2-[6-(4-pyrrolidin-1-ylmethylphenyl)pyrrolo[2,3-b]pyridin-1-yl]acetamide