(22R,23R,24R)-2α-benzyloxy-3β-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate

Base Information

Chemical Name:(22R,23R,24R)-2α-benzyloxy-3β-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate
CAS No.:1493793-40-0
Molecular Formula:C₅₂H₈₅BO₇
Molecular Weight:833.054
Hs Code.:

Synonyms:(22R,23R,24R)-2α-benzyloxy-3β-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate

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Chemical Property of (22R,23R,24R)-2α-benzyloxy-3β-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate

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Technology Process of (22R,23R,24R)-2α-benzyloxy-3β-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate

There total 6 articles about (22R,23R,24R)-2α-benzyloxy-3β-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1493793-39-7
(22R,23R,24R)-2α-benzyloxy-3β,22,23-trihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate

: 112-67-4
n-hexadecanoyl chloride

: 1493793-40-0
(22R,23R,24R)-2α-benzyloxy-3β-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate

Guidance literature:: In pyridine; at 20 ℃; for 5h;
DOI:10.1016/j.jsbmb.2013.01.016

Reference yield:

: 1244967-00-7
(22R,23R,24R)-2α,3α,22,23-tetrahydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate

: 1493793-40-0
(22R,23R,24R)-2α-benzyloxy-3β-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate

Guidance literature:: Multi-step reaction with 4 steps

1.1: di(n-butyl)tin oxide / toluene / 20 h / Reflux; Dean-Stark

1.2: 2 h / Reflux

2.1: pyridine / 1 h / 20 °C

3.1: sodium nitrite / N,N-dimethyl-formamide / 7 h / 100 °C

4.1: pyridine / 5 h / 20 °C

With di(n-butyl)tin oxide; sodium nitrite; In pyridine; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.jsbmb.2013.01.016

Reference yield:

: 100-39-0
benzyl bromide

: 1493793-40-0
(22R,23R,24R)-2α-benzyloxy-3β-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate

Guidance literature:: Multi-step reaction with 4 steps

1.1: di(n-butyl)tin oxide / toluene / 20 h / Reflux; Dean-Stark

1.2: 2 h / Reflux

2.1: pyridine / 1 h / 20 °C

3.1: sodium nitrite / N,N-dimethyl-formamide / 7 h / 100 °C

4.1: pyridine / 5 h / 20 °C

With di(n-butyl)tin oxide; sodium nitrite; In pyridine; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.jsbmb.2013.01.016