(E)-1-hydroxy-4-(3,5-dimethoxystiryl)-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine hydrochloride

Base Information

Chemical Name:(E)-1-hydroxy-4-(3,5-dimethoxystiryl)-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine hydrochloride
CAS No.:1352458-04-8
Molecular Formula:C₁₉H₂₇NO₃*ClH
Molecular Weight:353.889
Hs Code.:

Synonyms:(E)-1-hydroxy-4-(3,5-dimethoxystiryl)-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine hydrochloride

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Chemical Property of (E)-1-hydroxy-4-(3,5-dimethoxystiryl)-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine hydrochloride

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Technology Process of (E)-1-hydroxy-4-(3,5-dimethoxystiryl)-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine hydrochloride

There total 3 articles about (E)-1-hydroxy-4-(3,5-dimethoxystiryl)-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1352457-92-1
(E)-4-(3,5-dimethoxystiryl)-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridin-1-yloxyl

: 1352458-04-8
(E)-1-hydroxy-4-(3,5-dimethoxystiryl)-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; for 0.25h; Reflux;
DOI:10.1016/j.bmc.2011.10.066

Reference yield:

: 40243-87-6
3,5-dimethoxystyrene

: 1352458-04-8
(E)-1-hydroxy-4-(3,5-dimethoxystiryl)-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

2: hydrogenchloride / ethanol / 0.25 h / Reflux

With hydrogenchloride; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; 1: Heck reaction;
DOI:10.1016/j.bmc.2011.10.066

Reference yield:

: 78953-15-8
4-iodo-2,2,6,6-tetramethyl-3,6-dihydropyridin-1(2H)-yloxyl radical

: 1352458-04-8
(E)-1-hydroxy-4-(3,5-dimethoxystiryl)-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

2: hydrogenchloride / ethanol / 0.25 h / Reflux

With hydrogenchloride; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; 1: Heck reaction;
DOI:10.1016/j.bmc.2011.10.066