1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid

Base Information

Chemical Name:1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid
CAS No.:1366296-03-8
Molecular Formula:C₂₅H₃₀ClN₉O₆S
Molecular Weight:620.089
Hs Code.:

1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid

Synonyms:1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid

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Chemical Property of 1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid

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Technology Process of 1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid

There total 6 articles about 1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1366296-01-6
1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester

: 1366296-03-8
1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid

Guidance literature:: 1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

With sodium hydroxide; In water; ethyl acetate; pH=14;

With hydrogenchloride; In water; pH=6;

Reference yield:

: 1366068-08-7
1-cyano-cyclobutanecarboxylic acid tert-butyl ester

: 1366296-03-8
1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / Raney nickel / methanol / 2250.23 Torr / hydrogenation steel pressure vessel

2.1: dmap; triethylamine / dichloromethane / 2 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

3.2: pH 1

4.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5.2: pH 14

5.3: pH 6

With 4-methyl-morpholine; hydrogenchloride; dmap; water; hydrogen; triethylamine; HATU; sodium hydroxide; Raney nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1366068-12-3
1-(aminomethyl)cyclobutanecarboxylic acid tert-butyl ester

: 1366296-03-8
1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / dichloromethane / 2 h / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

2.2: pH 1

3.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4.2: pH 14

4.3: pH 6

With 4-methyl-morpholine; hydrogenchloride; dmap; water; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;