1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid dipropylcarbamoylmethyl ester

Base Information

Chemical Name:1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid dipropylcarbamoylmethyl ester
CAS No.:1366295-83-1
Molecular Formula:C₃₃H₄₅ClN₁₀O₇S
Molecular Weight:761.302
Hs Code.:

1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid dipropylcarbamoylmethyl ester

Synonyms:1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid dipropylcarbamoylmethyl ester

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Chemical Property of 1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid dipropylcarbamoylmethyl ester

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Technology Process of 1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid dipropylcarbamoylmethyl ester

There total 7 articles about 1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid dipropylcarbamoylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2315-37-9
2-chloro-N,N-dipropylacetamide

: 1366296-03-8
1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid

: 1366295-83-1
1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid dipropylcarbamoylmethyl ester

Guidance literature:: With sodium hydrogencarbonate; sodium iodide; In N,N-dimethyl-formamide; at 50 ℃; for 3.5h; Molecular sieve;

Reference yield:

: 1366068-08-7
1-cyano-cyclobutanecarboxylic acid tert-butyl ester

: 1366295-83-1
1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid dipropylcarbamoylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / Raney nickel / methanol / 2250.23 Torr / hydrogenation steel pressure vessel

2.1: dmap; triethylamine / dichloromethane / 2 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

3.2: pH 1

4.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5.2: pH 14

5.3: pH 6

6.1: sodium iodide; sodium hydrogencarbonate / N,N-dimethyl-formamide / 3.5 h / 50 °C / Molecular sieve

With 4-methyl-morpholine; hydrogenchloride; dmap; water; hydrogen; sodium hydrogencarbonate; triethylamine; HATU; sodium iodide; sodium hydroxide; Raney nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1366068-16-7
3-[(1-tert-butoxycarbonylcyclobutylmethyl)sulfamoyl]benzoic acid methyl ester

: 1366295-83-1
1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid dipropylcarbamoylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

1.2: pH 1

2.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.2: pH 14

3.3: pH 6

4.1: sodium iodide; sodium hydrogencarbonate / N,N-dimethyl-formamide / 3.5 h / 50 °C / Molecular sieve

With 4-methyl-morpholine; hydrogenchloride; water; sodium hydrogencarbonate; HATU; sodium iodide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;