1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester

Base Information

Chemical Name:1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester
CAS No.:1366296-01-6
Molecular Formula:C₂₉H₃₈ClN₉O₆S
Molecular Weight:676.196
Hs Code.:

1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester

Synonyms:1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester

Suppliers and Price of 1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester

There total 6 articles about 1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1160939-79-6
3,5-diamino-6-chloropyrazine-2-carboxylic acid [1,3,8-triazaspiro[4.5]dec-(2E)-ylidene]amide

: 1366067-60-8
3-[(1-tert-butoxycarbonylcyclobutylmethyl)sulfamoyl]benzoic acid

: 1366296-01-6
1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1366067-60-8
3-[(1-tert-butoxycarbonylcyclobutylmethyl)sulfamoyl]benzoic acid

: 3,5-diamino-6-chloropyrazine-2-carboxylic acid [1,3,8-triazaspiro[4.5]dec-(2E)-ylidene]amide hydrochloride

: 1366296-01-6
1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1116-98-9
cyanoacetic acid tert-butyl ester

: 1366296-01-6
1-[(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)methyl]cyclobutanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / sodium iodide / butanone / 80 °C

2.1: hydrogen / Raney nickel / methanol / 2250.23 Torr / hydrogenation steel pressure vessel

3.1: dmap; triethylamine / dichloromethane / 2 h / 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

4.2: pH 1

5.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With 4-methyl-morpholine; dmap; water; hydrogen; potassium carbonate; triethylamine; HATU; sodium hydroxide; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; butanone;