(R)-2-(phenylethynyl)-1-tosylpyrrolidine

Base Information

Chemical Name:(R)-2-(phenylethynyl)-1-tosylpyrrolidine
CAS No.:1580522-45-7
Molecular Formula:C₁₉H₁₉NO₂S
Molecular Weight:325.431
Hs Code.:

Synonyms:(R)-2-(phenylethynyl)-1-tosylpyrrolidine

Suppliers and Price of (R)-2-(phenylethynyl)-1-tosylpyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-(phenylethynyl)-1-tosylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-(phenylethynyl)-1-tosylpyrrolidine

There total 19 articles about (R)-2-(phenylethynyl)-1-tosylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1580522-23-1
(R)-methyl (6-(4-methylphenylsulfonamido)-1-phenylhex-1-yn-3-yl)carbonate

: 1580522-45-7
(R)-2-(phenylethynyl)-1-tosylpyrrolidine

: 1580522-47-9
(E)-6-benzylidene-1-tosyl-1,2,3,6-tetrahydropyridine

Guidance literature:: With bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; at 60 ℃; for 0.25h; Time; Solvent; Reagent/catalyst; Temperature; stereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.201309162

Reference yield: 62.0%

: 1580522-23-1
(R)-methyl (6-(4-methylphenylsulfonamido)-1-phenylhex-1-yn-3-yl)carbonate

: 1580522-45-7
(R)-2-(phenylethynyl)-1-tosylpyrrolidine

Guidance literature:: With Trimethyl borate; bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; at 60 ℃; for 0.25h; Time; Reagent/catalyst; Temperature; stereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.201309162

Reference yield:

: 18303-04-3
N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

: 1580522-45-7
(R)-2-(phenylethynyl)-1-tosylpyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: methyllithium / diethyl ether / 0.17 h / -20 °C / Inert atmosphere

3: (1S)-10-camphorsulfonic acid / methanol / 2 h / 20 °C / Inert atmosphere

4: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

5: bis(dibenzylideneacetone)-palladium⁽⁰⁾; bis[2-(diphenylphosphino)phenyl] ether; Trimethyl borate / 1,4-dioxane / 0.25 h / 60 °C / Inert atmosphere

With pyridine; Trimethyl borate; di-isopropyl azodicarboxylate; (1S)-10-camphorsulfonic acid; methyllithium; triphenylphosphine; bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane;
DOI:10.1002/anie.201309162