9-methyl-2,8,10-triazabicyclo[4.4.0]deca-2,4,8,11-tetraen-7-one

Base Information

• Chemical Name: 9-methyl-2,8,10-triazabicyclo[4.4.0]deca-2,4,8,11-tetraen-7-one
• CAS No.: 28279-12-1
• Molecular Formula: C8H7 N3 O
• Molecular Weight: 161.16
• Hs Code.: 2933990090
• Mol file: 28279-12-1.mol

Synonyms:Pyrido[2,3-d]pyrimidin-4(1H)-one,2-methyl- (9CI); Pyrido[2,3-d]pyrimidin-4-ol, 2-methyl- (6CI,8CI);2-Methylpyrido[2,3-d]pyrimidin-4-ol;3,4-Dihydro-2-methylpyrido[2,3-d]pyrimidin-4-one

Chemical Property of 9-methyl-2,8,10-triazabicyclo[4.4.0]deca-2,4,8,11-tetraen-7-one

Chemical Property:

• Vapor Pressure: 8.39E-05mmHg at 25°C
• Melting Point: 262-264℃ (methanol )
• Boiling Point: 340.8°Cat760mmHg
• Flash Point: 159.9°C
• PSA: 58.64000
• Density: 1.4g/cm³
• LogP: 0.62650

Purity/Quality:

98%min ^*data from raw suppliers

2-methylpyrido[2,3-d]pyrimidin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-methyl-2,8,10-triazabicyclo[4.4.0]deca-2,4,8,11-tetraen-7-one

There total 9 articles about 9-methyl-2,8,10-triazabicyclo[4.4.0]deca-2,4,8,11-tetraen-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-aminopyridine-3-carboxamide (13438-65-8) + Triethyl orthoacetate (78-39-7) → 2-methylpyrido[2,3-d]pyrimidin-4(3H)-one (28279-12-1)

Guidance literature:

With acetic acid; In ethanol; at 110 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.3390/molecules23112925

Reference yield: 49.0%

Trimethyl orthoacetate (1445-45-0) + 2-aminopyridin-3-carboxylic acid (5345-47-1) → 2-methylpyrido[2,3-d]pyrimidin-4(3H)-one (28279-12-1)

Guidance literature:

With ammonium acetate; In methanol; at 130 ℃; for 16h;

Reference yield: 48.0%

2-Methyl-4H-pyrido<2,3-d><3,1>oxazin-4-one (3809-93-6) → 2-methylpyrido[2,3-d]pyrimidin-4(3H)-one (28279-12-1)

Guidance literature:

With ammonium hydroxide; In water; at 20 ℃;

DOI:10.1021/acs.jmedchem.9b01198

upstream raw materials:

acetamide

2-aminopyridin-3-carboxylic acid

Trimethyl orthoacetate

2-fluoronicotinic acid chloride

Downstream raw materials:

2-methyl-4-chloropyrido<2,3-d>pyrimidine

4-[2-[4-methyl-2-propyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde