(R,R)-N-[3-(4-hydroxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide

Base Information

Chemical Name:(R,R)-N-[3-(4-hydroxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide
CAS No.:1050392-40-9
Molecular Formula:C₁₅H₁₆N₂O₂S
Molecular Weight:288.37
Hs Code.:

Synonyms:(R,R)-N-[3-(4-hydroxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,R)-N-[3-(4-hydroxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide

Chemical Property:

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Technology Process of (R,R)-N-[3-(4-hydroxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide

There total 8 articles about (R,R)-N-[3-(4-hydroxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1050392-36-3
4-(5-amino-4-methylisothiazol-3-yl)phenol

: 42274-66-8
2-methylcyclopropanecarbonyl chloride

: 1050392-40-9
(R,R)-N-[3-(4-hydroxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide

Guidance literature:: With pyridine; In tetrahydrofuran; toluene; for 1h;

Reference yield:

: 1050392-04-5
(S)-2-amino-3-phenyl-1-propanol (R,R)-2-methylcyclopropanecarboxylic acid salt

: 1050392-40-9
(R,R)-N-[3-(4-hydroxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 0.17 h

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 - 3 h / 0 - 40 °C / Heating / reflux

3: pyridine / tetrahydrofuran; toluene / 1 h

With pyridine; hydrogenchloride; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 20913-25-1
2-Methylcyclopropancarbonsaeureethylester

: 1050392-40-9
(R,R)-N-[3-(4-hydroxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; water / 1 - 4 h / 46 °C

2: ethyl acetate / 20 h / 20 - 70 °C / Resolution of racemate

3: hydrogenchloride / water / 0.17 h

4: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 - 3 h / 0 - 40 °C / Heating / reflux

5: pyridine / tetrahydrofuran; toluene / 1 h

With pyridine; hydrogenchloride; sodium hydroxide; oxalyl dichloride; water; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;