20913-25-1

Basic information

• Product Name: ETHYL 2-METHYLCYCLOPROPANE-1-CARBOXYLATE
• Synonyms: ETHYL 2-METHYLCYCLOPROPANE-1-CARBOXYLATE;ETHYL 2-METHYLCYCLOPROPANECARBOXYLATE;Cyclopropanecarboxylic acid, 2-methyl-, ethyl ester;Ethyl 2-methylcyclopropane;2-Methylcyclopropanecarboxylic acid ethyl ester
• CAS NO: 20913-25-1
• Molecular Formula: C₇H₁₂O₂
• Molecular Weight: 128.17
• EINECS: 244-113-5
• Product Categories: Esters;Ring Systems
• Mol File: 20913-25-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 147 °C
• Boiling Point: 75°C 11mm
• Flash Point: 42.2 °C
• Appearance: /
• Density: 1.0195 (rough estimate)
• Vapor Pressure: 3.65mmHg at 25°C
• Refractive Index: 1.4800 (estimate)
• CAS DataBase Reference: ETHYL 2-METHYLCYCLOPROPANE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-METHYLCYCLOPROPANE-1-CARBOXYLATE(20913-25-1)
• EPA Substance Registry System: ETHYL 2-METHYLCYCLOPROPANE-1-CARBOXYLATE(20913-25-1)

Safety Data

• Statements: 10
• Safety Statements: 23-24/25-16
• RIDADR: 1993
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 20913-25-1(Hazardous Substances Data)

Usage

Uses

Ethyl 2-Methylcyclopropane-1-carboxylate is used in preparation of N-Isothiazolyl Carboxamides useful in the treatment of pain.

Synthesis Reference(s)

Journal of the American Chemical Society, 81, p. 1660, 1959 DOI: 10.1021/ja01516a037

InChI:InChI=1/C7H12O2/c1-3-9-7(8)6-4-5(6)2/h5-6H,3-4H2,1-2H3

Upstream product

• 70775-39-2 dimethylsulfoxonium methylide 
• 623-70-1 ethyl (E)-crotonate 
• 108-29-2 5-methyl-dihydro-furan-2-one 
• 25966-39-6 3-bromo-5-methyldihydrofuran-2(3H)-one 
• 64-17-5 ethanol 
• 86725-67-9 (2-oxo-5-methyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester 
• 1774-47-6 trimethylsulfoxonium iodide 
• 70786-82-2 ethyl 4-chloropentanoate 

Downstream Products

• 29555-02-0 2-methyl-cyclopropanecarboxylic acid 
• 6142-57-0 (+/-)-trans-2-methylcyclopropanecarboxylic acid 
• 10487-86-2 (1R,2R)-2-methylcyclopropanecarboxylic acid 
• 42274-66-8 2-methylcyclopropanecarboxylic acid chloride 
• 1050392-04-5 (S)-2-amino-3-phenyl-1-propanol (R,R)-2-methylcyclopropanecarboxylic acid salt 
• 1050392-96-5 (R,R)-N-[4-bromo-3-(3-fluoro-4-methoxyphenyl)isothiazol-5-yl]-2-methyl-cyclopropanecarboxamide 
• 1050393-31-1 (R,R)-N-[3-(3-fluoro-4-methoxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide 
• 1050393-15-1 (R,R)-N-[4-bromo-3-(4-ethoxyphenyl)isothiazol-5-yl]-2-methylcyclopropanecarboxamide 
• 1050392-92-1 (R,R)-N-[3-[4-(1,1-difluoroethyl)phenyl]isothiazol-5-yl]-2-methylcyclopropanecarboxamide 
• 1050392-79-4 (R,R)-N-[3-(3-fluoro-4-methoxyphenyl)isothiazol-5-yl]-2-methyl-cyclopropanecarboxamide 
• 1050393-35-5 (R,R)-N-[3-(4-ethoxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide 
• 1050392-40-9 (R,R)-N-[3-(4-hydroxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide 
• 1050393-47-9 (R,R)-N-[3-(4-chlorophenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide 
• 1050393-23-1 (1R,2R)-N-(3-(4-methoxyphenyl)-4-methylisothiazol-5-yl)-2-methylcyclopropanecarboxamide 

Relevant articles and documents

SUBSTITUTED CARBOXAMIDES

This application relates to a substituted carboxamide compound of formula I, or a pharmaceutically acceptable salt thereof, as defined herein, a pharmaceutical composition thereof, and its use in treating pain.

Picosecond Radical Kinetics. Alkoxycarbonyl Accelerated Cyclopropylcarbinyl Radical Ring Openings

Rate constants and Arrhenius functions for ring openings of the (trans-2-ethoxycarbonylcyclopropyl)methyl radical and the (trans-2-tert-butoxycarbonylcyclopropyl)methyl radical were determined by the PTOC-thiol method with PhSeH trapping.At 25 deg C, these radicals rearrange with rate constants of 7 and 12*1010 s-1, respectively.

THE ASYMMETRIC SYNTHESIS OF CIS-SUBSTITUTED CYCLOPROPANECARBOXYLIC ACID DERIVATIVES

The asymmetric synthesis of cis-substituted cyclopropanecarboxylic acid derivatives is achieved via stereoselective electrophilic methylene transfer to Z-α,β-unsaturated acyl ligands bound to the iron chiral auxiliary 5-C5H5)Fe(CO)(PPH3)>.