(1R,2S)-2-<2'-<(tert-Butyldimethylsilyl)oxy>ethyl>cyclohexaneacetic acid methyl ester

Base Information

Chemical Name:(1R,2S)-2-<2'-<(tert-Butyldimethylsilyl)oxy>ethyl>cyclohexaneacetic acid methyl ester
CAS No.:144236-01-1
Molecular Formula:C₁₇H₃₄O₃Si
Molecular Weight:314.541
Hs Code.:

Synonyms:(1R,2S)-2-<2'-<(tert-Butyldimethylsilyl)oxy>ethyl>cyclohexaneacetic acid methyl ester

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Chemical Property of (1R,2S)-2-<2'-<(tert-Butyldimethylsilyl)oxy>ethyl>cyclohexaneacetic acid methyl ester

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Technology Process of (1R,2S)-2-<2'-<(tert-Butyldimethylsilyl)oxy>ethyl>cyclohexaneacetic acid methyl ester

There total 3 articles about (1R,2S)-2-<2'-<(tert-Butyldimethylsilyl)oxy>ethyl>cyclohexaneacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 144236-00-0
(1R,2S)-2-(2'-Hydroxyethyl)cyclohexaneacetic acid methyl ester

: 144236-01-1
(1R,2S)-2-<2'-<(tert-Butyldimethylsilyl)oxy>ethyl>cyclohexaneacetic acid methyl ester

Guidance literature:: With dmap; triethylamine; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jo00077a058

Reference yield:

: 112168-18-0
(1R-cis)-4-cyclohexene-1,2-diacetic acid monomethyl ester

: 144236-01-1
(1R,2S)-2-<2'-<(tert-Butyldimethylsilyl)oxy>ethyl>cyclohexaneacetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / H₂ / 5percent Pd/C / ethanol / 5 h / 2844.3 Torr

2: 96 percent / diborane / tetrahydrofuran

3: 80 percent / (dimethylamino)pyridine, triethylamine / dimethylformamide / Ambient temperature

With dmap; hydrogen; triethylamine; diborane; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00077a058

Reference yield:

: 144301-38-2
(1R,2S)-Methyl hydrogen cis-1,2-cyclohexanediacetate

: 144236-01-1
(1R,2S)-2-<2'-<(tert-Butyldimethylsilyl)oxy>ethyl>cyclohexaneacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / diborane / tetrahydrofuran

2: 80 percent / (dimethylamino)pyridine, triethylamine / dimethylformamide / Ambient temperature

With dmap; triethylamine; diborane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00077a058